CCN3 Protein & Antibody (NOV, IGFBP9)

CCN family member 3 (Nephroblastoma Overexpressed Gene, Insulin-like Growth Factor Binding Protein 9 )

CCN3 Protein Products

CCN3 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CCN3/NOV/IGFBP9	Human	CCN3/NOV/IGFBP9 Protein, Recombinant	10264-H08B

  10264-H08B:  When cells are added to CCN3 coated plates (10 µg/mL, 100 µL/well), 50%-60% will adhere specifically after 60 minutes at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of Balb/3T3 mouse embryonic fibroblast cells.

CCN3 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CCN3/NOV/IGFBP9	WB, ELISA	CCN3/NOV/IGFBP9 Antibody, Mouse Mab	10264-MM05
Human CCN3/NOV/IGFBP9	WB, ELISA	CCN3 / NOV (IGFBP9) Antibody	10264-R130
Human CCN3/NOV/IGFBP9	WB, ELISA	Rabbit Polyclonal Antibody	10264-RP01
Human CCN3/NOV/IGFBP9	WB, ELISA, IHC-P	CCN3 / NOV / IGFBP9 Antibody (Antigen Affinity Purified)	10264-RP02

CCN3 ELISA Kits

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CCN3/NOV/IGFBP9	ELISA	CCN3 / NOV / IGFBP9 ELISA Pair Set, Human ELISA Pair Set	SEK10264

CCN3 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CCN3/NOV/IGFBP9	Human	Human NOV/CCN3 cDNA Clone / ORF Clone	HG10264-M
CCN3/NOV/IGFBP9	Mouse	Mouse NOV/CCN3 cDNA Clone / ORF Clone	MG50455-M
CCN3/NOV/IGFBP9	Canine	Canine NOV Gene cDNA Clone / ORF Clone	DG70043-G
CCN3/NOV/IGFBP9	Cynomolgus	Cynomolgus monkey NOV cDNA Clone / ORF Clone	CG90081-G

CCN3 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>CCN3/NOV/IGFBP9

Cancer>>Growth Factor & Receptor>>IGF System>>CCN3/NOV/IGFBP9

Cancer>>Growth Factor & Receptor>>Other>>CCN3/NOV/IGFBP9

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>CCN3/NOV/IGFBP9

CCN3 Alternative Names

CCN3, NOV, IGFBP9, IBP-9, IGF-binding protein 9, IGFBP-9 [Homo sapiens]

CCN3, Nov, C130088N23Rik [Mus musculus]

CCN3 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
CCN4/WISP1	Human	CCN4/WISP1 Protein, Recombinant
IGF1R/CD221	Human	IGF1R/CD221 Protein, Recombinant
IGFBP3	Human	IGFBP3 Protein, Recombinant
IGFBP4	Human	IGFBP4 Protein, Recombinant
IGFBP4	Mouse	IGFBP4 Protein, Recombinant
IGFBP6	Human	IGFBP6 Protein, Recombinant
IGFBP6	Mouse	IGFBP6 Protein, Recombinant
Insulin Receptor/CD220	Human	Insulin Receptor/CD220 Protein, Recombinant
Insulin Receptor/CD220	Human	Insulin Receptor/CD220 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human IGF1R/CD221	WB	Mouse Monoclonal Antibody
Human IGF1R/CD221	WB	Mouse Monoclonal Antibody
Human IGF1R/CD221	ELISA	Mouse Monoclonal Antibody
Human IGF1R/CD221	WB, ELISA	Rabbit Monoclonal Antibody
Human IGF1R/CD221	ELISA	Rabbit Polyclonal Antibody
Human IGF1R/CD221	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human IGFBP3	WB, ELISA	Mouse Monoclonal Antibody
Human IGFBP4	WB, ELISA	Mouse Monoclonal Antibody
Human Insulin Receptor/CD220	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
CCN4/WISP1	Human	Homo sapiens CCN4/WISP1 cDNA Clone(NM_003882.2)
IGF1R /CD221	Human	Homo sapiens IGF1R /CD221 cDNA Clone(NM_000875.3)
IGFBP3	Human	Homo sapiens IGFBP3 cDNA Clone(NM_000598.4)
IGFBP4	Human	Homo sapiens IGFBP4 cDNA Clone(NM_001552.2)
IGFBP4	Mouse	Mus musculus IGFBP4 cDNA Clone
IGFBP5	Human	Homo sapiens IGFBP5 cDNA Clone(NM_000599.3)
IGFBP5	Mouse	Mus musculus IGFBP5 cDNA Clone
IGFBP6	Human	Human IGFBP6 cDNA Clone / ORF Clone
IGFBP6	Mouse	Mus musculus IGFBP6 cDNA Clone

CCN3 Background

Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development , and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.

CCN3 Related Studies

1. Manara MC, et al. (2002) The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol. 160(3): 849-59.
2. Lin CG, et al. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 278(26): 24200-8.
3. Vallacchi V, et al. (2009) CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma. Cancer Res. 68(3): 715-23.
4. Sin WC, et al. (2009) Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization. J Biol Chem. 284(43): 29935-44.
5. McCallum L, et al. (2009) CCN3--a key regulator of the hematopoietic compartment. Blood Rev. 23(2): 79-85.