Anti-NOV / CCN3 Antibody

Cat: 10264-RP01
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Anti-NOV / CCN3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-NOV / CCN3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human NOV / CCN3
Immunogen
Recombinant Human NOV protein (Catalog#10264-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant full length of human NOV / CCN3 (rh NOV; Catalog#10264-H08B; NP_002505.1; Met 1-Met 357). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-NOV / CCN3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-NOV / CCN3 Antibody Alternative Names
Anti-CCN3 Antibody;Anti-IBP-9 Antibody;Anti-IGFBP-9 Antibody;Anti-IGFBP9 Antibody;Anti-NOVh Antibody
NOV / CCN3 Background Information

Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development , and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.

Full Name
nephroblastoma overexpressed
References
  • Manara MC, et al. (2002) The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol. 160(3): 849-59.
  • Lin CG, et al. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 278(26): 24200-8.
  • Vallacchi V, et al. (2009) CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma. Cancer Res. 68(3): 715-23.
  • Sin WC, et al. (2009) Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization. J Biol Chem. 284(43): 29935-44.
  • McCallum L, et al. (2009) CCN3--a key regulator of the hematopoietic compartment. Blood Rev. 23(2): 79-85.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-NOV / CCN3 Antibody Rabbit Polyclonal ELISA 90081-T16
    Anti-NOV / CCN3 Antibody Rabbit Polyclonal ELISA 90081-RP01
    Anti-NOV / CCN3 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 10264-RP02
    Anti-NOV / CCN3 Antibody Mouse Monoclonal ELISA 10264-MM05
    Anti-NOV / CCN3 Antibody Rabbit Monoclonal ELISA 10264-R130
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