CCL8 / MCP-2 Protein

Chemokine (C-C motif) Ligand 8 / Monocyte Chemotactic Protein 2

CCL8 / MCP-2 Products

CCL8 / MCP-2 Protein, Recombinant

Molecule	Species	Description	Cat. No
CCL8/MCP-2	Human	CCL8/MCP-2 Protein, Recombinant, with SUMO Tag	10989-H21E
CCL8/MCP-2	Mouse	CCL8/MCP-2 Protein, Recombinant, with NusA Tag	50181-M24E

CCL8 / MCP-2 cDNA Clone

Molecule	Species	Description	Cat. No
CCL8/MCP-2	Human	Homo sapiens CCL8/MCP-2 cDNA Clone	HG10989-M
CCL8/MCP-2	Mouse	Mus musculus CCL8/MCP-2 cDNA Clone	MG50181-M

CCL8 / MCP-2 Related Areas

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CCL8/MCP-2

CCL8 / MCP-2 Alternative Names

CCL8, MCP-2, HC14, MCP2, SCYA10, SCYA8 [Homo sapiens]

Ccl8, MCP-2, RP23-446K18.1, 1810063B20Rik, AB023418, HC14, Mcp2, Scya8 [Mus musculus]

CCL8 / MCP-2 Background

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.

CCL8 / MCP-2 Related Studies

1. Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28 (5): 443-60.
2. Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8⁺ T cells. Science. 270 (5243): 1811–5.
3. Hori T, et al. (2008) CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood. 111 (8): 4403-12.
4. Biber K, et al. (2003) Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Journal of Leukocyte Biology. 74 (2): 243-51.