CCL5 / RANTES Protein

Chemokine (C-C motif) Ligand 5

CCL5 / RANTES Products

CCL5 / RANTES Protein, Recombinant

Molecule	Species	Description	Cat. No
CCL5/RANTES	Human	CCL5/RANTES/Mucin-stalk Protein, Recombinant	10900-H14H

CCL5 / RANTES cDNA Clone

Molecule	Species	Description	Cat. No
CCL5/RANTES	Human	Homo sapiens CCL5/RANTES cDNA Clone(NM_002985.2)	HG10900-M
CCL5/RANTES	Mouse	Mus musculus CCL5/RANTES cDNA Clone	MG50022-M
CCL5/RANTES	Rat	Rattus norvegicus CCL5/RANTES cDNA Clone	RG80038-M

CCL5 / RANTES Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>CCL5/RANTES

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CCL5/RANTES

Immunology>>Innate Immunity>>Granulocyte>>Eosinophil granulocyte>>CCL5/RANTES

CCL5 / RANTES Alternative Names

CCL5, RANTES, SISd, SCYA5, D17S136E, MGC17164, TCP228 [Homo sapiens]

Ccl5, RANTES, SISd, Scya5, MuRantes, TCP228 [Mus musculus]

CCL5 / RANTES Background

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 5(CCL5) is chemotactic for T cells, basophils and eosinophils. Chemokin ligand 5(CCL5) has been considered a HIV-supressor secreted by CD8⁺ T cells and other immune cells. Chemokin ligand 5(CCL5) is a key to activating recruit leukocytes into inflammatory sites and in the presence of particular cytokines released by T cells, it can change the NK cells into CHAK cells.

CCL5 / RANTES Related Studies

1. Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.
2. Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8⁺ T cells. Science. 270 (5243): 1811–5.
3. Vangelista L, et al. (2010) Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers. Antimicrob. Agents Chemother. 54 (7): 2994–3001.
4. Maghazachi AA, et al. (1996) CC chemokines induce the generation of killer cells from CD56⁺ cells. Eur. J. Immunol. 26 (2): 315–9.