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>Cynomolgus CCL17 / TARC Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Chemokine (C-C motif) ligand 17 Protein Datasheet
CCL17 / TARC Protein Price Inquiry ( Available Sizes )
CCL17 / TARC Protein Product Information
|Synonym :||CCL17, TARC|
A DNA sequence encoding the cynomolgus CCL17 (Q8HYP9) (Met1-Ser94) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Baculovirus-Insect cells|
CCL17 / TARC Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
CCL17 / TARC protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ala 24|
The recombinant heterodimer of cynomolgus CCL17 comprises 81 amino acids and has a calculated molecular mass of 9.5 KDa. The apparent molecular mass of the protein is approximately 10 KDa respectively in SDS-PAGE.
|Formulation:||Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly.
CCL17 / TARC Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CCL17 / TARC Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CCL17/TARC||Human||CCL17/TARC Protein, Recombinant||10233-H08B|
|CCL17/TARC||Human||CCL17/TARC Protein, Recombinant, Native||10233-HNAB|
|CCL17/TARC||Mouse||CCL17 / TARC Protein, Recombinant||50046-MNAB|
|CCL17/TARC||Cynomolgus||CCL17 / TARC Protein, Recombinant||90077-C08B|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human CCL17/TARC||WB, ELISA||10233-RP02|
|Human CCL17/TARC||WB, ELISA||10233-MM03|
CCL17 / TARC Protein Description
C-C motif chemokine 17, also known as CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CCL17 and SCYA17, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. Chemokines are known to regulate the steady-state and inflammatory migration of cutaneous dendritic cells (DCs). The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases. CCL17 / SCYA17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts. CCL17 / SCYA17 is expressed at high levels in thymus and at low levels in the lung, colon and small intestine. CCL17 / SCYA17 is a chemotactic factor for T-lymphocytes but not monocytes or granulocytes. It may play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. CCL17 / SCYA17 binds to CCR4.Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune disease.
- Belperio JA. et al., 2004, J Immunol. 173 (7): 4692-8.
- Carpenter KJ. et al., 2005, Infect Immun. 73 (11): 7198-207.
- Saeki H. et al., 2006, J Dermatol Sci. 43 (2): 75-84.
- Niens M. et al., 2008, Br J Haematol. 140 (5): 527-36.
- Stutte S. et al., 2010, Proc Natl Acad Sci. 107 (19): 8736-41.