Gene Summary: CCL14 gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by CCL14 gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for CCL14 gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]General information above from NCBI
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cofactor: Binds 1 magnesium ion per monomer.
Subunit structure: Monomer (By similarity). Interacts with REST.
Subcellular location: Secreted.
Tissue specificity: Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
Induction: In primary sarcomas.
Post-translational: The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal- GalNAc disaccharide, further modified by two N-acetylneuraminic acids.
Sequence similarity: Belongs to the intercrine beta (chemokine CC) family.