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CAT/Catalase  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Baculovirus-Insect Cells  
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CAT/Catalase Related Pathways

    CAT/Catalase Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CAT/Catalase Summary & Protein Information

    CAT/Catalase Background

    Gene Summary: This CAT gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
    General information above from NCBI
    Catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O.
    Cofactor: Heme group.
    Subunit structure: Homotetramer.
    Subcellular location: Peroxisome.
    Post-translational: The N-terminus is blocked.
    Involvement in disease: Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the catalase family.
    General information above from UniProt

    Catalase is a ubiquitously expressed enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a tetramer of four polypeptides chains containing four porphyrin heme groups that allow the enzyme to react with the hydrogen peroxide. The optimum PH of human catalase is approximately 7 and the optimum temperature is at 37 degree. Both the PH optimum and temperature for other catalases varies depending on the species. Catalase can be inhibited by a flux of O2- generated in situ by the aerobic xanthine oxidase reaction. This inhibition of catalase by O2- provides the basis for a synergism between superoxide dismutase and catalase.Such synergisms have been observed in vitro and may be significant in vivo. Catalase is used in the food industry for removing hydrogen peroxide from milk prior to cheese production. Another use is in food wrappers where it prevents food from oxidizing. Catalase is also used in the textile industry, removing hydrogen peroxide from fabrics to make sure the material is peroxide-free.

    CAT/Catalase Alternative Name

    MGC138422,MGC138424, [human]
    RP23-266F3.2,2210418N07,Cas1,Cas-1,Cs-1, [mouse]
    Cas1,Cs-1,Cas-1,2210418N07, [mus-musculus]

    CAT/Catalase Related Studies

  • Schriner SE. et al., 2005, Science. 308 (5730): 1909-11.
  • Kono Y. et al., 1982, The Journal of Biological Chemistry. 257: 5751-4.