Caspase-9 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Caspase-9 reagents are produced in house and quality controlled, including 1 Caspase-9 Antibody, 15 Caspase-9 Gene, 1 Caspase-9 IP Kit, 1 Caspase-9 qPCR. All Caspase-9 reagents are ready to use.

Caspase-9 Antibody (1)

Caspase-9 cDNA Clone (15)

Caspase-9 qPCR Primer (1)

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Caspase-9 Background

Neural tube defects (NTDs) are birth defects of the nervous system and are the second most frequent cause of birth defects worldwide. The etiology of NTDs is complicated and involves both genetic and environmental factors. CASP9 is an initiator caspase in the intrinsic apoptosis pathway, which in Casp9-/- mice has been shown to result in NTDs because of decreased apoptosis. HSP9 inhibitors are identified here as a pharmacological approach for targeting autophagy via destabilization of ATG7, while an induced expression of CASP9, but not its apoptotic activity, is identified as a resistance mechanism to the cellular stress brought about by HSP9 inhibition.