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CANT1Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
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10 µg 
20 µg 
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Expression host: Human Cells  
  • Slide 1
10 µg 
20 µg 
Add to Cart

CANT1 Related Pathways

CANT1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

CANT1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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CANT1 Summary & Protein Information

CANT1 Background

Gene Summary: This protein encoded by this CANT1 gene belongs to the apyrase family. CANT1 functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
General information above from NCBI
Catalytic activity: A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
Cofactor: Calcium.
Subunit structure: Monomer.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Processed form: Secreted.
Tissue specificity: Widely expressed.
Post-translational: N-glycosylated.
Involvement in disease: Desbuquois dysplasia (DBQD) [MIM:251450]: A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the apyrase family.
General information above from UniProt

CANT1(calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC that catalyses the hydrolysis of ATP to yield AMP and inorganic phosphate. Two isoenzymes are found in commercial preparations from S. tuberosum. One with a higher ratio of substrate selectivity for ATP: ADP and another with no selectivity. It can also act on ADP and other nucleoside triphosphates and diphosphates with the general reaction being NTP -> NDP + Pi -> NMP + 2Pi. The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes are implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. CANT1 functions as a calcium-dependent nucleotidase with a preference for UDP. Defects in CANT1 are the cause of desbuquois dysplasia.

CANT1 Alternative Name

micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification, []
DBQD,SCAN1,SHAPY,SCAN-1, [homo-sapiens]
apyrase homolog,Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase,DBQD,isozyme 1,putative MAPK-activating protein PM09,putative NF-kappa-B-activating protein 107,SCAN1,SCAN-1,SHAPY,soluble Ca-activated nucleotidase,soluble calcium-activated nucleotidase 1,soluble calcium-activated nucleotidase SCAN-1, [human]
5830420C20Rik,Apy1h,apyrase 1,apyrase homolog,Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase,D11Bwg0554e,Entpd8,homolog (C. lectularius),RP23-394O9.5,SCAN-1,Shapy,soluble calcium-activated nucleotidase 1, [mouse]
Apy1h,Shapy,Entpd8,SCAN-1,D11Bwg0554e,5830420C20Rik, [mus-musculus]

CANT1 Related Studies

  • Failer BU, et al. (2002) Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase. J Biol Chem. 277(40):36978-86.
  • Smith TM, et al. (2002) Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases. Arch Biochem Biophys. 406(1):105-15.
  • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.