CAMK4 / CaMKIV Protein

Calcium/calmodulin-dependent protein kinase IV

CAMK4 / CaMKIV Products

CAMK4 / CaMKIV Protein, Recombinant

Molecule	Species	Description	Cat. No
CAMK4/CaMKIV	Human	CAMK4/CaMKIV Protein, Recombinant, with GST Tag	10664-H09B
CAMK4/CaMKIV	Mouse	CAMK4 / CaMKIV Protein, Recombinant, with GST Tag	50838-M20B

CAMK4 / CaMKIV cDNA Clone

Molecule	Species	Description	Cat. No
CAMK4/CaMKIV	Human	Homo sapiens CAMK4/CaMKIV cDNA Clone	HG10664-M
CAMK4/CaMKIV	Mouse	Mouse CAMK4/CaMKIV cDNA Clone / ORF Clone	MG50838-G

CAMK4 / CaMKIV Related Areas

Neuroscience>>Synaptic Protein>>CAMK4/CaMKIV

Enzyme>>Protein Kinase>>Intracellular Kinase>>CaM Kinase>>CAMK4/CaMKIV

Signal Transduction>>Calcium Signaling>>CaM Kinase>>CAMK4/CaMKIV

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>CAMK4/CaMKIV

CAMK4 / CaMKIV Alternative Names

CAMK4, CaMK IV, CaMK-GR, IV, MGC36771, caMK [Homo sapiens]

Camk4, caMK IV, A430110E23Rik, AI666733, CaMKIV, CaMKIV/Gr, D18Bwg0362e [Mus musculus]

CAMK4 / CaMKIV Background

Ca²⁺/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca²⁺/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme implicated in the phophoinositide amplification cascade. Ca²⁺/calmodulin dependent protein kinase (CAMK) can be activated by the introcellular increased Ca²⁺ and then apt to combine with the target protein. Ca²⁺/ calmodulin-dependent protein kinase 4 (CAMKⅣ) is a multifunctional CaM-dependent kinase protein with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. All of the isforms of this family, including myosin light chain kinase, phosphorylase kinase, CaMK1, CaMKⅢ and CaMKⅣ have EF-hand structure.

CAMK4 / CaMKIV Related Studies

1. Feliciano DM, et al. (2009) Repression of Ca²⁺/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. J Biol Chem. 284 (39): 26466–81.
2. Zhao X, et al. (2001). The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem. 276 (37): 35042–8.
3. Racioppi L, et al. (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.