Anti-CALML5 Antibody

Cat: 11783-RP02
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Anti-CALML5 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CALML5 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CALML5
Immunogen
Recombinant Human CALML5 protein (Catalog#11783-H20E)
Preparation
Produced in rabbits immunized with purified, recombinant Human CALML5 (rh CALML5; Catalog#11783-H20E; AAH39172.1; Met 1-Glu 146). CALML5 specific IgG was purified by Human CALML5 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CALML5 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CALML5 Antibody (Rabbit Polyclonal antibody) Images
Human CALML5 Immunohistochemistry(IHC) 4608
Immunochemical staining of human CALML5 in human skin (from donor 2) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.
Human CALML5 Immunohistochemistry(IHC) 4609
Immunochemical staining of human CALML5 in human skin (from donor 1) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Human CALML5 Immunohistochemistry(IHC) 4610
Immunochemical staining of human CALML5 in human mammary adenocarcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium.
Anti-CALML5 Antibody Alternative Names
Anti-CLSP Antibody
CALML5 Background Information

Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains four EF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. CALML5 / CLSP is closely related to CAR. The structure and dynamics of human calmodulin-like skin protein CALML5 / CLSP have been characterized by NMR spectroscopy. The mobility of CALML5 / CLSP has been found to be different for the N-terminal and C-terminal domains. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain.

Full Name
calmodulin like 5
References
  • Mehul B., et al., 2000, J. Biol. Chem. 275:12841-12847.
  • Babini E., et al., 2006, Structure 14:1029-1038.
  • Kawabata,K. et al., 2007, Gene Ther. 14 (16):1199-207.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CALML5 Antibody Rabbit Polyclonal ELISA 11783-RP01
    Anti-CALML5 Antibody Mouse Monoclonal ELISA,ELISA(Det) 11783-MM01
    Anti-CALML5 Antibody Rabbit Monoclonal IHC-P 11783-R119
    Anti-CALML5 Antibody Mouse Monoclonal ELISA(Cap) 11783-MM08
    Anti-CALML5 Antibody Rabbit Monoclonal ELISA,ICC/IF,IF 11783-R158
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