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CADM4/IGSF4C/NECL-4 Protein, Antibody, ELISA Kit, cDNA Clone

CADM4/IGSF4C/NECL-4 Related Areas

CADM4/IGSF4C/NECL-4 Related Pathways

CADM4/IGSF4C/NECL-4 Related Product

    CADM4/IGSF4C/NECL-4 Summary & Protein Information

    CADM4/IGSF4C/NECL-4 Background

    Subunit structure: Monomer and homodimer.
    Subcellular location: Membrane; Single-pass type I membrane protein (Potential).
    Tissue specificity: Expressed in brain, prostate, brain, kidney and some other organs.
    Post-translational: N-glycosylated (By similarity).
    Sequence similarity: Belongs to the nectin family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    General information above from UniProt

    Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.

    CADM4/IGSF4C/NECL-4 Alternative Name

    CADM4,IGSF4C,NECL4,Necl-4,synCAM4,TSLL2, [human]
    CADM4,Igdf4c,Igsf4c,NECL-4,Tsll2, [mouse]

    CADM4/IGSF4C/NECL-4 Related Studies

  • Williams YN, et al. (2006) Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Oncogene. 25(10): 1446-53.
  • Ohta Y, et al. (2005) Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system. Brain Res Dev Brain Res. 156(1): 23-31.
  • Shingai T, et al. (2003) Implications of nectin-like molecule-2 /IGSF4 /RA175 /SgIGSF /TSLC1 /SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. 278(37): 35421-7.