CADM4 / IGSF4C / NECL-4 Protein

Cell adhesion molecule 4 / Immunoglobulin superfamily member 4C / Nectin-like protein 4

CADM4 / IGSF4C / NECL-4 Products

CADM4 / IGSF4C / NECL-4 Protein, Recombinant

Molecule	Species	Description	Cat. No
CADM4/IGSF4C/NECL-4	Mouse	CADM4/IGSF4C/NECL-4 Protein, Recombinant	50501-M08H

CADM4 / IGSF4C / NECL-4 cDNA Clone

Molecule	Species	Description	Cat. No
CADM4/IGSF4C/NECL-4	Mouse	Mouse CADM4/IGSF4C/NECL-4 cDNA Clone / ORF Clone	MG50501-M

CADM4 / IGSF4C / NECL-4 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CADM4/IGSF4C/NECL-4

CADM4 / IGSF4C / NECL-4 Alternative Names

CADM4, IGSF4C, Necl-4, NECL4, TSLL2, synCAM4 [Homo sapiens]

CADM4, Igsf4c, NECL-4, Igdf4c, Tsll2 [Mus musculus]

CADM4 / IGSF4C / NECL-4 Background

Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.

CADM4 / IGSF4C / NECL-4 Related Studies

1. Williams YN, et al. (2006) Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Oncogene. 25(10): 1446-53.
2. Ohta Y, et al. (2005) Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system. Brain Res Dev Brain Res. 156(1): 23-31.
3. Shingai T, et al. (2003) Implications of nectin-like molecule-2 /IGSF4 /RA175 /SgIGSF /TSLC1 /SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. 278(37): 35421-7.