CADM3 / NECL1 Protein & Antibody (IGSF4B)

Cell Adhesion Molecule 3 / Nectin-like 1 (Immunoglobulin superfamily, member 4B)

CADM3 / NECL1 Products

CADM3 / NECL1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CADM3/NECL1/IGSF4B	Human	CADM3/NECL1/IGSF4B Protein, Recombinant	11214-H08H
CADM3/NECL1/IGSF4B	Mouse	CADM3/NECL1/IGSF4B Protein, Recombinant	50476-M08H
CADM3/NECL1/IGSF4B	Rat	CADM3 / IGSF4B / NECL1 Protein, Recombinant	80220-R08H

  11214-H08H: Human CADM3 immobilized at 0.8 µg/mL, 100 µL/well will mediate > 30% C6 cell adhesion. Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells.

CADM3 / NECL1 Antibody

Molecule	Application	Description	Cat. No
Human CADM3/NECL1/IGSF4B	WB, ELISA	CADM3/NECL1/IGSF4B Antibody, Rabbit MAb	11214-R003
Human CADM3/NECL1/IGSF4B	WB, ELISA	Rabbit Polyclonal Antibody	11214-RP01
Human CADM3/NECL1/IGSF4B	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11214-RP02
Mouse CADM3/NECL1/IGSF4B	WB, ELISA	CADM3/NECL1/IGSF4B Antibody, Rabbit PAb	50476-RP01
Mouse CADM3/NECL1/IGSF4B	WB, ELISA	CADM3/NECL1/IGSF4B Antibody, Rabbit PAb (Antigen Affinity Purified)	50476-RP02
Mouse CADM3/NECL1/IGSF4B	WB, ELISA	CADM3 / NECL1 / IGSF4B Antibody	50476-R024
Mouse CADM3/NECL1/IGSF4B	WB, ELISA	CADM3 / NECL1 / IGSF4B Antibody	50476-R035

CADM3 / NECL1 cDNA Clone

Molecule	Species	Description	Cat. No
CADM3/NECL1/IGSF4B	Human	Homo sapiens CADM3/NECL1/IGSF4B DNA ORF clone(NM_021189)	HG11214-M
CADM3/NECL1/IGSF4B	Mouse	Mus musculus CADM3/NECL1/IGSF4B cDNA Clone	MG50476-M
CADM3/NECL1/IGSF4B	Rat	Rat CADM3/NECL1/IGSF4B cDNA Clone	RG80220-G

CADM3 / NECL1 Alternative Names

CADM3, NECL1, IGSF4B, Necl-1, BIgR, TSLL1, synCAM3, CTA-134P22.1, FLJ10698 [Homo sapiens]

Cadm3, Necl1, Igsf4b, Necl-1, BIgR, Tsll1, SynCAM3 [Mus musculus]

CADM3 / NECL1 Related Areas

Neuroscience>>Synaptic Protein>>CADM3/NECL1/IGSF4B

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>CADM3/NECL1/IGSF4B

CADM3 / NECL1 Background

Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.

CADM3 / NECL1 Related Studies

1. Dong X, et al. (2006) Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem. 281(15): 10610-7.
2. Gao J, et al. (2008) Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity. Biochim Biophys Acta. 1778(6): 1429-35.
3. Gao J, et al. (2009) Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. Glia. 57(9): 989-99.