Anti-CADM3 Antibody

Cat: 50476-R035
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Anti-CADM3 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CADM3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CADM3
Immunogen
Recombinant Mouse CADM3 / NECL1 / IGSF4B Protein (Catalog#50476-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CADM3 / NECL1 / IGSF4B (rM CADM3 / NECL1 / IGSF4B; Catalog#50476-M08H; NP_444429.1; Met 1-His 328).
Source
Monoclonal Rabbit IgG Clone #035
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CADM3 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CADM3 Antibody Alternative Names
Anti-BIgR Antibody;Anti-Igsf4b Antibody;Anti-Necl-1 Antibody;Anti-Necl1 Antibody;Anti-SynCAM3 Antibody;Anti-Tsll1 Antibody
CADM3 Background Information

Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.

Full Name
cell adhesion molecule 3
References
  • Dong X, et al. (2006) Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem. 281(15): 10610-7.
  • Gao J, et al. (2008) Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity. Biochim Biophys Acta. 1778(6): 1429-35.
  • Gao J, et al. (2009) Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. Glia. 57(9): 989-99.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CADM3 Antibody Rabbit Polyclonal ELISA 50476-RP01
    Anti-CADM3 Antibody Rabbit Polyclonal ELISA 50476-RP02
    Anti-CADM3 Antibody Rabbit Polyclonal WB,ELISA 50476-T48
    Anti-CADM3 Antibody Rabbit Monoclonal ELISA 50476-R024
    Anti-CADM3 Antibody Rabbit Monoclonal ELISA 11214-R003
    Anti-CADM3 Antibody Rabbit Polyclonal ELISA 11214-RP01
    Anti-CADM3 Antibody Rabbit Polyclonal ELISA 11214-RP02
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