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C8B  Protein, Antibody, ELISA Kit, cDNA Clone

C8B Related Pathways

    C8B Related Protein, Antibody, cDNA Gene, and ELISA Kits

    C8B Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    C8B Summary & Protein Information

    C8B Background

    Subunit structure: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
    Subcellular location: Secreted.
    Post-translational: N-glycosylated; contains one or two bound glycans. Not O- glycosylated.
    Involvement in disease: Complement component 8 deficiency, 2 (C8D2) [MIM:613789]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 TSP type-1 domains.
    General information above from UniProt

    C8B Alternative Name

    C8B Related Studies

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"