All C1QB reagents are produced in house and quality controlled, including 1 C1QB Antibody, 26 C1QB Gene, 1 C1QB Lysate, 1 C1QB Protein, 2 C1QB qPCR. All C1QB reagents are ready to use.
Recombinant C1QB proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.
C1QBantibodies are validated with different applications, which are IHC-P.
C1QBcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each C1QB of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Southern blot analysis of chromosomal DNA from vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. C1q was already present at embryonic day 14 (E14) and showed little change in abundance through six weeks postnatal. At E16, C1qB mRNA was present at high abundance in putative microglia/macrophages in cortical marginal and intermediate zones, and hippocampal analge.