C1qB Protein

Complement Component 1, q subcomponent, B chain

C1qB Products

C1qB Protein, Recombinant

Molecule	Species	Description	Cat. No
C1qB	Human	C1qB Protein, Recombinant	10941-H08B

C1qB cDNA Clone

Molecule	Species	Description	Cat. No
C1qB	Human	Homo sapiens C1qB cDNA Clone	HG10941-M
C1qB	Mouse	Mus musculus C1qB cDNA Clone	MG50295-M

C1qB Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Complement System>>C1qB

Immunology>>Innate Immunity>>Complement System>>C1qB

C1qB Alternative Names

C1QB

C1qB  Protein Related Products

Recombinant Protein Products

Molecule	Application	Description
C1QBP/HABP1	Human	C1QBP/HABP1 Protein, Recombinant
C1QBP/HABP1	Mouse	C1QBP/HABP1 Protein, Recombinant
Complement C1s	Human	Complement C1s Protein, Recombinant
Complement C2	Human	Complement C2/Fc Protein, Recombinant
Complement C2	Human	Complement C2 Protein, Recombinant
Complement C5a	Human	Complement C5a Protein, Recombinant
Complement Factor H/CFH	Human	Complement Factor H/CFH Protein, Recombinant
CD55/DAF	Human	CD55/DAF/Fc Protein, Recombinant
CD55/DAF	Human	CD55/DAF Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human CD55/DAF	WB, ELISA	Rabbit Polyclonal Antibody
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
Complement C1s	Human	Homo sapiens Complement C1s transcript variant 1 cDNA Clone(NM_001734.2)
Complement C1r	Human	Homo sapiens Complement C1r cDNA Clone(NM_001733.4)
C1qB	Human	Homo sapiens C1qB cDNA Clone(NM_000491.3)
Complement C2	Human	Homo sapiens Complement C2 cDNA Clone(NM_000063.3)
adipsin/Complement Factor D	Human	Homo sapiens adipsin/Complement Factor D cDNA Clone(NM_001928.2)
Complement Factor H/CFH	Human	Homo sapiens Complement Factor H/CFH cDNA Clone
CD55/DAF	Human	Homo sapiens CD55/DAF transcript variant 1 cDNA Clone(NM_000574.3)

C1qB Background

Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Southern blot analysis of chromosomal DNA from vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. C1q was already present at embryonic day 14 (E14) and showed little change in abundance through six weeks postnatal. At E16, C1qB mRNA was present at high abundance in putative microglia/macrophages in cortical marginal and intermediate zones, and hippocampal analge.

C1qB Related Studies

1. Pasinetti GM, et al. (1992) Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Experimental neurology. 118(2): 117-25.
2. Johnson SA, et al. (1994) Expression of complement C1qB and C4 mRNAs during rat brain development. Brain Res Dev Brain Res. 80(1-2): 163-74.
3. Grewal RP,et al. (1999) C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neuroscience letters. 271(1): 65-7.
4. Spielman L, et al. (2002) Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta neuropathologica. 103(2): 157-62.