All C1QBP reagents are produced in house and quality controlled, including 9 C1QBP Antibody, 32 C1QBP Gene, 4 C1QBP IPKit, 2 C1QBP Protein, 2 C1QBP qPCR. All C1QBP reagents are ready to use.
Recombinant C1QBP proteins are expressed by E. coli with fusion tags as C-His, N-His.
C1QBPantibodies are validated with different applications, which are ELISA, FCM, ICC/IF, IF, WB, IHC-P, IP.
C1QBPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each C1QBP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Hyaluronan binding protein 1 (HABP1), also known as p32 or gC1qR, is a ubiquitously expressed multifunctional phospho-protein implicated in cell signalling. Hyaluronan-binding protein 1 (HABP1) /p32/gC1qR was characterized as a highly acidic and oligomeric protein, which binds to different ligands like hyaluronan, C1q, and mannosylated albumin. The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro. HABP1 overexpressing cells showed extensive vacuolation and reduced growth rate, which was corrected by frequent medium replenishment. Further investigation revealed that HABP1 overexpressing cells undergo apoptosis, and they failed to enter into the S-phase. The sperm surface HABP1 level can be correlated with the degree of sperm motility.Hyaluronan binding protein 1 (HABP1) was reported to be present on human sperm surface and its involvement in fertilization has already been elucidated: decreased HABP1 level may be associated with low motility of sperms, which in turn might cause infertility in the patient. HABP1 also is an endogenous substrate for MAP kinase and upon mitogenic stimulation it is translocated to the nucleus in a MAP kinase-dependent manner.