C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
C10orf54 (GI24) Proteins
C10orf54 (GI24) Antibodies
C10orf54 (GI24) ELISA Pair sets
C10orf54 (GI24) cDNA Clones
RP11-472K8.3, B7-H5, B7H5, GI24, PP2135, SISP1, platelet receptor Gi24, stress induced secreted protein 1 [Homo sapiens]
Wikipedia summary for C10orf54 (GI24):
Platelet receptor Gi24 is a protein that in humans is encoded by the C10orf54 gene.
Platelet receptor Gi24
Contains 1 Ig-like (immunoglobulin-like) domain.
The sequence AAL55778.1 differs from that shown. Reason: Erroneous termination at position 84. Translated as Ser.
|Subcellular location:||Membrane; Single-pass type I membrane protein|
General information above from UniProt