C10orf54 (GI24)

C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

C10orf54 (GI24) Alternative Names

RP11-472K8.3, B7-H5, B7H5, GI24, PP2135, SISP1, platelet receptor Gi24, stress induced secreted protein 1 [Homo sapiens]

Summaries for C10orf54 (GI24)

Wikipedia summary for C10orf54 (GI24):

Platelet receptor Gi24 is a protein that in humans is encoded by the C10orf54 gene.

Human C10orf54 (GI24) Protein General Information

 

• Protein names: Platelet receptor Gi24
• Sequence length: 311 AA.
• Domain: Immunoglobulin domain
  Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Contains 1 Ig-like (immunoglobulin-like) domain.
• Sequence caution: The sequence AAL55778.1 differs from that shown. Reason: Erroneous termination at position 84. Translated as Ser.
  The sequence AAL55778.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
  The sequence BAB15739.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
• Subcellular location: Membrane; Single-pass type I membrane protein

General information above from UniProt

Function for C10orf54 (GI24) Protein

Genatlas:

• unknown