- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Chromosome 10 open reading frame 54 Protein Datasheet
C10orf54 / GI24 Protein Price Inquiry ( Available Sizes )
C10orf54 / GI24 Protein Product Information
|Synonym :||Gi24, VISTA, B7H5, C10orf54|
A DNA sequence encoding the human Gi24 (AAH20568.1) (Met1-Ala194) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
C10orf54 / GI24 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
C10orf54 / GI24 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Phe 33|
The recombinant human Gi24 consists of 173 amino acids and predicts a molecular mass of 19.6 KDa. It migrates as an approximately 38-42 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
C10orf54 / GI24 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
C10orf54 / GI24 Protein Related Products & Topics
C10orf54 / GI24 Protein Description
C10orf54, also known as GI24, is a member of the immunoglobulin superfamily. As a transmembrane molecule, C10orf54 is expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
- Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.
- Deloukas P. et al., 2004, Nature. 429 (6990): 375-81.
- Colland F. et al., 2004, Genome Res. 14 (7): 1324-32.