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> C1 inhibitor / SerpinG1 Protein & Antibody (C1INH, C1NH) C1 inhibitor / SerpinG1 Protein & Antibody (C1INH, C1NH)
Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
C1 inhibitor / SerpinG1 Products
C1 inhibitor / SerpinG1 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| C1 inhibitor/SerpinG1 | Human | C1 inhibitor/SerpinG1 Protein, Recombinant | 10995-H08H |
C1 inhibitor / SerpinG1 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human C1 inhibitor/SerpinG1 |
WB, ELISA | Mouse Monoclonal Antibody | 10995-MM03 |
| Human C1 inhibitor/SerpinG1 |
WB, ELISA | C1 inhibitor/SerpinG1 Antibody, Rabbit MAb | 10995-R018 |
| Human C1 inhibitor/SerpinG1 |
WB, ELISA | Rabbit Polyclonal Antibody | 10995-RP01 |
| Human C1 inhibitor/SerpinG1 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10995-RP02 |
C1 inhibitor / SerpinG1 ELISA Kit
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human C1 inhibitor/SerpinG1 |
ELISA | C1 inhibitor/SerpinG1 ELISA Kit | SEK10995 |
C1 inhibitor / SerpinG1 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| C1 inhibitor/SerpinG1 | Human | Homo sapiens C1 inhibitor/SerpinG1 cDNA Clone(NM_000062.2) | HG10995-M |
C1 inhibitor / SerpinG1 Related Areas
Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>C1 inhibitor/SerpinG1
Immunology>>Innate Immunity>>Complement System>>C1 inhibitor/SerpinG1
C1 inhibitor / SerpinG1 Alternative Names
C1 inhibitor, SERPING1, C1INH, C1NH, C1IN, HAE1, HAE2 [Homo sapiens]
C1 inhibitor, Serping1, C1INH, C1nh, RP23-399J8.3 [Mus musculus]
C1 inhibitor / SerpinG1 Related Products
Protein Products
Antibody Products
cDNA Clone Products
C1 inhibitor / SerpinG1 Background
Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.
C1 inhibitor / SerpinG1 Related Studies
- Davis AE 3rd. et al. (2004) Biological effects of C1 inhibitor. Drug News Perspect. 17(7): 439-46.
- Cicardi M, et al. (2005) C1 inhibitor: molecular and clinical aspects. Springer Semin Immunopathol. 27(3): 286-98.
- Wouters D, et al. (2008) C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor. Expert Opin Biol Ther. 8(8): 1225-40.
- Cugno M, et al. (2009) C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress. Trends Mol Med. 15(2): 69-78.
