Anti-C1 inhibitor Antibody

Cat: 10995-MM03
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Anti-C1 inhibitor Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-C1 inhibitor Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human C1 inhibitor
No cross-reactivity in ELISA with Human SerpinA1 / A1AT Human SerpinF1 / PEDF Human SerpinF2 / AAP Human SerpinA5 / PROCI Human SerpinI1 / PI12 Human SerpinC1 / Antithrombin-III Mouse SerpinD1 / HCF2 Mouse SerpinF2 / AAP / PLI
Immunogen
Recombinant Human SerpinG1 protein (Catalog#10995-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinG1 (rh SerpinG1; Catalog#10995-H08H; NP_000053.2; Met 1-Ala 500). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #8D4C12E6
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-C1 inhibitor Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-C1 inhibitor Antibody Alternative Names
Anti-C1IN Antibody;Anti-C1INH Antibody;Anti-C1NH Antibody;Anti-HAE1 Antibody;Anti-HAE2 Antibody
C1 inhibitor Background Information

Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.

Full Name
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
References
  • Davis AE 3rd. et al. (2004) Biological effects of C1 inhibitor. Drug News Perspect. 17(7): 439-46.
  • Cicardi M, et al. (2005) C1 inhibitor: molecular and clinical aspects. Springer Semin Immunopathol. 27(3): 286-98.
  • Wouters D, et al. (2008) C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor. Expert Opin Biol Ther. 8(8): 1225-40.
  • Cugno M, et al. (2009) C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress. Trends Mol Med. 15(2): 69-78.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-C1 inhibitor Antibody Rabbit Polyclonal ELISA 10995-RP01
    Anti-C1 inhibitor Antibody Rabbit Polyclonal WB,ELISA,IHC-P 10995-RP02
    Anti-C1 inhibitor Antibody Mouse Monoclonal ELISA(Cap) 10995-MM06
    Anti-C1 inhibitor Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det),IP 10995-R018
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