Anti-C1 inhibitor Antibody

Cat: 10995-RP02

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Anti-C1 inhibitor Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-C1 inhibitor Antibody
Validated applications
Species reactivity
Reacts with: Human
Human C1 inhibitor
Recombinant Human SerpinG1 protein (Catalog#10995-H08H)
Produced in rabbits immunized with purified, recombinant Human SerpinG1 (rh SerpinG1; Catalog#10995-H08H; NP_000053.2; Met 1-Ala 500). SerpinG1 specific IgG was purified by human SerpinG1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-C1 inhibitor Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-C1 inhibitor Antibody (Rabbit Polyclonal antibody) Images
Human C1 inhibitor/SerpinG1 Immunohistochemistry(IHC) 3613
Immunochemical staining of human serpinG1 in human lung with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human C1 inhibitor/SerpinG1 Western blot (WB) 13319

Anti-SerpinG1 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:56 kDa

Observed band size:53 kDa

(We are unsure as to the identity of these extra bands.)

Anti-C1 inhibitor Antibody Alternative Names
Anti-C1IN Antibody;Anti-C1INH Antibody;Anti-C1NH Antibody;Anti-HAE1 Antibody;Anti-HAE2 Antibody
C1 inhibitor Background Information

Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.

Full Name
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
  • Davis AE 3rd. et al. (2004) Biological effects of C1 inhibitor. Drug News Perspect. 17(7): 439-46.
  • Cicardi M, et al. (2005) C1 inhibitor: molecular and clinical aspects. Springer Semin Immunopathol. 27(3): 286-98.
  • Wouters D, et al. (2008) C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor. Expert Opin Biol Ther. 8(8): 1225-40.
  • Cugno M, et al. (2009) C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress. Trends Mol Med. 15(2): 69-78.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-C1 inhibitor Antibody Rabbit Polyclonal ELISA 10995-RP01
    Anti-C1 inhibitor Antibody Mouse Monoclonal ELISA 10995-MM03
    Anti-C1 inhibitor Antibody Mouse Monoclonal ELISA(Cap) 10995-MM06
    Anti-C1 inhibitor Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det),IP 10995-R018
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