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Bone Morphogenetic Protein (BMP) & Receptor

Bone Morphogenetic Protein (BMP) & Receptor

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    Bone Morphogenetic Protein (BMP) & Receptor Background

    Bone morphogenetic proteins (BMPs) are secreted signaling molecules known for their ability to induce the formation of bone and cartilage. Since then, twenty BMPs have been discovered. BMPs interact with specific receptors on the cell surface and activate the BMP signaling pathways, which is involved in the development of the heart, central nervous system, and cartilage, as well as post-natal bone development. For their important role during embryonic development on the embryonic patterning and early skeletal formation, Mutations in BMPs and their inhibitors (such as sclerostin) are associated with a number of human disorders which affect the skeleton. In addition, bone morphogenetic proteins can also act as axon guidance molecules.

    Bone Morphogenetic Protein (BMP) & Receptor References

      1. Kakaiya R. (1990) Bone morphogenetic protein. Clin Orthop Relat Res. Apr;(253):309-10.
      2. Thomas BG, et al. (2000) Bone morphogenetic protein-6: potential mediator of osteoblastic metastases in prostate cancer. Prostate Cancer Prostatic Dis. 3(4):283-285.
      3. Wang Q, et al. (2007) Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. J Biol Chem. 282(14):10742-8.
      4. Orazizadeh M, et al. (2009) Effect of bone morphogenetic protein-2 on normal and osteoarthritic human articular chondrocytes. Pak J Biol Sci. 12(17):1194-9.
      5. Solmesky LJ, et al. (2009) Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium. Stem Cells Dev. 18(9):1283-92.