Betacellulin Protein (BTC Protein)

Betacellulin Products

Betacellulin Protein, Recombinant

Molecule	Species	Description	Cat. No
Betacellulin/BTC	Human	Betacellulin/BTC Protein, Recombinant	12192-H08E
Betacellulin/BTC	Mouse	Betacellulin/BTC/Fc Protein, Recombinant	50340-M03H

Betacellulin cDNA Clone

Molecule	Species	Description	Cat. No
Betacellulin/BTC	Human	BTC cDNA Clone / ORF Clone	HG12192-G
Betacellulin/BTC	Mouse	Mus musculus Betacellulin/BTC cDNA Clone	MG50340-M
Betacellulin/BTC	Cynomolgus	BTC cDNA Clone / ORF Clone	KG90033-G

Betacellulin Alternative Names

Betacellulin, BTC, probetacellulin [Homo sapiens]

Betacellulin, Btc, probetacellulin [Mus musculus]

Betacellulin Related Areas

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>Betacellulin/BTC

Betacellulin Background

Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of about 62-111 amino acid residues. Secondary Structure: 6% helical (1 helices; 3 residues)36% beta sheet (5 strands; 18 residues). BTC was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. It plays a role in the growth and development of the neonate and/or mammary gland function. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Betacellulin Related Studies

1. Shing Y, et al. (1993) Betacellulin: a mitogen from pancreatic beta cell tumors. Science . 259(5101): 1604-7.
2. Riese DJ, et al. (1996) Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene. 12(2): 345-53.
3. Bastian SE, et al.  (2001) Measurement of betacellulin levels in bovine serum, colostrum and milk. J Endocrinol . 168: 203-12.