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BTLA  Protein

All BTLA Reagents

Expression host: Human Cells  
  • Slide 1
11895-H02H-50
11895-H02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
51060-M02H-50
51060-M02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
81142-R05H-50
81142-R05H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90250-C02H-50
90250-C02H-100
50 µg 
100 µg 
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BTLA Related Pathways

BTLA Summary & Protein Information

BTLA Background

Gene Summary: BTLA gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
General information above from NCBI
Subunit structure: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.
Subcellular location: Membrane; Single-pass type I membrane protein (Potential).
Post-translational: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.
N-glycosylated.
Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

BTLA Alternative Name

BTLA1,CD272, [homo-sapiens]
B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,BTLA1,CD272, [human]
A630002H24,B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein, [mouse]
A630002H24, [mus-musculus]

BTLA Related Studies

  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"