BTLA

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

BTLA Alternative Names

BTLA1, CD272, B and T lymphocyte attenuator, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein [Homo sapiens]

A630002H24, B and T lymphocyte attenuator, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein [Mus musculus]

Summaries for BTLA

Entrez Gene summary for BTLA:

BTLA gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

Wikipedia summary for BTLA:

B- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene.
BTLA has also been designated as CD272 (cluster of differentiation 272).

Human BTLA Protein General Information

 

• Protein names: B- and T-lymphocyte attenuator
  Short name=BTLA
• Sequence length: 289 AA.
• Domain: Immunoglobulin domain
  Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• Post-translational modification: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
• Subunit structure: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Sequence caution: The sequence BAD18396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

General information above from UniProt

Function for BTLA Protein

UniProtKB:

BTLA is lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

Genatlas:

• BTLA inhibits antigen-induced production of IL-2

Homology for human BTLA

• homolog to murine Btla