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Mouse BTLA Protein (Fc Tag)
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Mouse BTLA Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
51060-M02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

B and T lymphocyte associated Protein Datasheet

 

BTLA Protein Price Inquiry ( Available Sizes )

BTLA Protein Product Information

Synonym : BTLA
Protein Construction:

A DNA sequence encoding the mouse BTLA(Met1-Gly176) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Mouse
Expression Host: Human Cells

BTLA Protein QC Testing

Purity: > 90 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

BTLA protein

Bio-activity:

Immobilized mouse BTLA-Fc at 10 μg/ml (100 μl/well) can bind biotinylated mouse HVEM-Fch (Cat:10567-M03S), The EC50 of biotinylated mouse HVEM-Fch (Cat:10567-M03S) is 15.7-36.7 ng/ml.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Glu 30
Molecular Mass:

The recombinant mouse BTLA /Fc is a disulfide-linked homodimer. The reduced monomer comprises 388 amino acids and has a predicted molecular mass of 437 kDa. The apparent molecular mass of the protein is approximately 57-62 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

BTLA Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BTLA Protein Related Products & Topics

Related Areas:

Proteins:

Antibodies:

BTLA Protein Description

BTLA is a member of the immunoglobulin superfamily. It contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is one of a growing number of inhibitory molecules that down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis.

References

  1. Fourcade J. et al., 2012, Cancer Res. 72 (4): 887-96.
  2. Kojima R. et al., 2011, J Mol Biol. 413 (4): 762-72.
  3. Oki M. et al., 2011, Clin Dev Immunol. 305656.
 

 

BTLA related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"