BTK Protein

Bruton agammaglobulinemia tyrosine kinase

BTK Products

BTK Protein, Recombinant

Molecule	Species	Description	Cat. No
BTK	Human	BTK Protein, Recombinant	10578-H07B

  10578-H07B:

1. The specific activity of BTK was determined to be 55 nmol/min/mg using a Poly (Glu:Tyr, 4:1) synthetic peptide substrate.

2. Measured by its ability to bind human BLNK in a functional Elisa.

BTK cDNA Clone

Molecule	Species	Description	Cat. No
BTK	Human	Homo sapiens BTK cDNA Clone	HG10578-M
BTK	Mouse	Mus musculus BTK cDNA Clone	MG50607-M

BTK Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>BTK

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>BTK

Immunology>>Adaptive Immunity >>B Cell>>BTK

BTK Alternative Names

BTK, RP1-164F3.2, AGMX1, AT, ATK, BPK, IMD1, MGC126261, MGC126262, PSCTK1, XLA [Homo sapiens]

Btk, RP23-91G19.5, AI528679, xid [Mus musculus]

BTK Background

Bruton's tyrosine kinase (or BTK) is a type of kinase protein expressed in B lymphocytes and T cells. BTK contains a PH domain which binds phosphatidylinositol(3,4,5)-trisphosphate (PIP3). After binding to PIP3, BTK is induced to phosphorylate phospholipase C, which in turn hydrolyzes PIP2 into two second messagers, IP3 and DAG, which then modulate the activity of downstream proteins during B-cell signaling. Btk is also found implicated in the primary immunodeficiency disease X-linked agammaglobulinemia(Bruton's agammaglobulinemia). BTK played a key role in B-cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with X-linked agammaglobulinemia have normal pre-B cell populations in their bone marrow but these B-cells can not mature and enter the circulation.

BTK Related Studies

1. Hashimoto S, et al. (1996) Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. Blood. 88(2): 561-73.
2. Ohta Y, et al. (1994) Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia. PNAS. 91(19): 9062-6.
3. Smith C, et al. (1994) Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells. The Journal of Immunology. 152(2): 557-65.