BST2 Protein

Bone marrow stromal cell antigen 2

BST2 Products

BST2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No	Price / Size
BST2	Human	TETHERIN / BST2 / CD317 Protein, Recombinant	13370-H01H	$290 / 50µg
BST2	Human	TETHERIN / BST2 / CD317 Protein, Recombinant	13370-H07H	$290 / 50µg
BST2	Mouse	BST2 Protein, Recombinant	51043-M01H	$290 / 50µg

BST2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No	Price / Size
BST2	Human	BST2 cDNA Clone / ORF Clone	HG13370-G	$95
BST2	Mouse	BST2 cDNA Clone / ORF Clone	MG51043-G	$95
BST2	Rat	BST2 cDNA Clone / ORF Clone	RG80417-G	$95

BST2 Related Areas

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> BST2/CD317

BST2 Alternative Names

2310015I10Rik, Bst-2, C87040, DAMP-1, GREG, DAMP-1 protein homolog; HM1.24 antigen; bone marrow stromal antigen 2 [Mus musculus]

BST2 Background

Tetherin, also known as bone marrow stromal antigen 2, CD317, and BST2, is single-pass type II membrane protein with an extracellular coiled coil domain forms a long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading. BST2 / CD317 predominantly expressed in liver, lung, heart and placenta and low levels in pancreas, kidney, skeletal muscle and brain. This protein is found overexpressed in multiple myeloma cells. It is highly expressed during B-cell development, from pro-B precursors to plasma cells, and on T-cells, monocytes, NK cells and dendritic cells. BST2 / CD317 is involved in the sorting of secreted proteins and in pre-B cell growth. As an antiretroviral defense protein, BST2 blocks release of enveloped virus from the cell surface. Active against at least four virus families: retroviruses, filoviruses, arenaviruses, and herpesviruses. BST2 / CD317 is discovered as an inhibitor to HIV-1 infection in the absence of Vpu and it inhibits the release of other viruses such as the Lassa and Marburg virions.

BST2 Related Studies

1. Ishikawa J, et al. (1995) Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 26 (3): 527-34.
2. Viswanathan K, et al. (2011) BST2/Tetherin enhances entry of human cytomegalovirus. PLoS Pathog. 7(11):e1002332.
3. Gifford RJ. (2011) No trespassing: ancient BST2 deletion confers protection against simian immunodeficiency virus infection of humans. Hum Mutat. 32(11).