BPIFA2 / C20orf70 Protein (His Tag)

BPI fold containing family A, member 2 Protein Datasheet

BPIFA2 / C20orf70 Protein Product Information

• Synonym: C20orf70, BPIFA2,SPLUNC2
• Protein Construction: A DNA sequence encoding the human C20orf70 (Q96DR5) (Met1-Ile249) was expressed with a polyhistidine tag at the C-terminus.
• Source: Human
• Expression Host: Human Cells

BPIFA2 / C20orf70 Protein QC Testing

• Purity: > 85% as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Glu 19
• Molecular Mass: The recombinant human C20orf70 consists of 242 amino acids and predicts a molecular mass of 26.5 KDa. It migrates as an approximately 35 KDa band in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: BPIFA2 / C20orf70 protein

BPIFA2 / C20orf70 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BPIFA2 / C20orf70 Protein Description

C20orf70 is a member of the BPI/LBP/Plunc superfamily, Plunc family. PLUNC family is composed of mucosal secretory proteins that are predicted to be structurally similar to lipid-binding and host-defense proteins including bactericidal/permeability-increasing protein and lipopolysaccharide-binding protein. C20orf70 is expected to have molecular function (lipid binding) and to localize in extracellular region. It is a salivary protein of unknown function. C20orf70 can be detected in submandibular gland. C20orf70 gene contains 9 distinct gt-ag introns. Transcription produces 6 different mRNAs, 4 alternatively spliced variants and 2 unspliced forms. There are 2 probable alternative promotors, 3 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 3' end. 80 bp of this gene are antisense to spliced gene glopa, raising the possibility of regulated alternate expression.

References

1. Lamesch P. et al., 2007, Genomics. 89 (3): 307-15.
2. Vargas PA. et al., 2008, Oral Dis. 14 (7): 613-9.
3. Bingle L. et al., 2009, Histochem Cell Biol. 132 (3): 339-49.