BNIP-2- like (BNIPL), also known as Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like, is a apaptosis-associated protein that shares 72% homology with BNIP-2. BNIPL is highly expressed in human placenta and lung. There are two alternative splices: BNIPL-1 and BNIPL-2. Both BNIPL-1 and BNIPL-2 have a conserved arginine-patch motif in Rho protein family. BNIPL-1 has function in suppressing cell growth through binding to MIF (macrophage migration inhibitory factor) and GFER (growth factor erv1(saccharomyces cerevisiae)-like). BNIPL-2 may suppress the Cdc42GAP's activity through ineracting with Cdc42GAP. BNIPL-2, containg a key BCH domain, which may induce the cell pseudopod growth, takes part in modulating cell migrations. Thus it suggested BNIPL-2 implicated in cell migration progresses and tumor translocation.
BNIPL ELISA Pair sets
BNIPL cDNA Clones
BNIPL, RP11-316M1.7, BNIP-S, BNIPL-1, BNIPL-2, PP753 [Homo sapiens]
Bnipl, 1700128A13Rik, BNIP-S, BNIPL1, BNIPL2, MGC8103, PP73, PP753 [Mus musculus]
Entrez Gene summary for BNIPL:
The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
OMIM - description for BNIPL:
Using yeast 2-hybrid and pull-down affinity studies, Qin et al. (2003) showed that the BCH domain of the BNIPL2 isoform interacted with Bcl2 (151430), Cdc42GAP, and with itself. They demonstrated that the BCH domain was responsible for the ability of BNIPL2 to suppress GAP activity of Cdc42GAP toward CDC42 (116952) and for the proapoptotic function of BNIPL2. Shen et al. (2003) showed that overexpression of BNIPL inhibited cell growth in human hepatocarcinoma cells. Using in vivo and in vitro assays, they found that BNIPL interacted with MIF (153620) and GFER (600924).
Wikipedia summary for BNIPL:
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene
Recommended name: Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Contains 1 CRAL-TRIO domain.
Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER
Isoform 2 is expressed in placenta and lung.
General information above from UniProt
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death
- BNIPL is implicated in the suppression of cell death
- BNIPL may be playing an important role in regulation of both pathways for DNA fragmentation and for formation of membrane blebs in apoptotic cells
- BNIPL might inhibit cell growth though cell cycle arrest and/or apoptotic cell death pathway(s)
- BNIPL induce apoptosis and/or necrosis
- BNIPL may play its roles in apoptosis through regulating the expression of genes associated with cell apoptosis, growth inhibition and cell proliferation
- BNIPL promotes the invasion and metastasis of human hepatocellular carcinoma cells
- homolog to BNIP2