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BNIPLProtein, Antibody, ELISA Kit, cDNA Clone

BNIPL Related Pathways

BNIPL Related Protein, Antibody, cDNA Gene, and ELISA Kits

BNIPL Related Protein, Antibody, cDNA Gene, and ELISA Kits

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BNIPL Summary & Protein Information

BNIPL Background

Gene Summary: The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
General information above from NCBI
Subunit structure: Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.
Tissue specificity: Isoform 2 is expressed in placenta and lung.
Sequence similarity: Contains 1 CRAL-TRIO domain.C
General information above from UniProt

BNIP-2- like (BNIPL), also known as Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like, is a apaptosis-associated protein that shares 72% homology with BNIP-2. BNIPL is highly expressed in human placenta and lung. There are two alternative splices: BNIPL-1 and BNIPL-2. Both BNIPL-1 and BNIPL-2 have a conserved arginine-patch motif in Rho protein family. BNIPL-1 has function in suppressing cell growth through binding to MIF (macrophage migration inhibitory factor) and GFER (growth factor erv1(saccharomyces cerevisiae)-like). BNIPL-2 may suppress the Cdc42GAP’s activity through ineracting with Cdc42GAP. BNIPL-2, containg a key BCH domain, which may induce the cell pseudopod growth, takes part in modulating cell migrations. Thus it suggested BNIPL-2 implicated in cell migration progresses and tumor translocation.

BNIPL Alternative Name

BNIPS,PP753,BNIP-S,BNIPL1,BNIPL2,BNIPL-1,BNIPL-2, [homo-sapiens]
BNIPL-1,BNIPL-2,BNIP-S,PP753,BNIPL,RP11-316M1.7, [human]
BNIPL1,BNIPL2,MGC8103,PP753,1700128A13Rik,Bnipl,BNIP-S,PP73, [mouse]
PP73,PP753,BNIP-S,BNIPL1,BNIPL2,1700128A13Rik, [mus-musculus]

BNIPL Related Studies

  • Shen L, et al. (2003) The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. FEBS. 540(1-3): 86-90.
  • Qin WX, et al. (2003) BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. Biochemical and Biophysical Research Communications. 308(2): 379-85.
  • Yasuda M, et al. (1999) BNIP3 alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res. 59 (3): 533-7.
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