BNIPL Protein

BCL2/adenovirus E1B 19kD interacting protein like

BNIPL Products

BNIPL Protein, Recombinant

Molecule	Species	Description	Cat. No
BNIPL	Human	BNIPL Protein, Recombinant	11460-HNCE

BNIPL cDNA Clone

Molecule	Species	Description	Cat. No
BNIPL	Human	Human BNIPL cDNA Clone / ORF Clone	HG11460-M

BNIPL Related Areas

Cancer>>Apoptosis>>Bcl-2 Family>>BNIPL

BNIPL Alternative Names

BNIPL, RP11-316M1.7, BNIP-S, BNIPL-1, BNIPL-2, PP753 [Homo sapiens]

Bnipl, 1700128A13Rik, BNIP-S, BNIPL1, BNIPL2, MGC8103, PP73, PP753 [Mus musculus]

BNIPL Background

BNIP-2- like (BNIPL), also known as Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like, is a apaptosis-associated protein that shares 72% homology with BNIP-2. BNIPL is highly expressed in human placenta and lung. There are two alternative splices: BNIPL-1 and BNIPL-2. Both BNIPL-1 and BNIPL-2 have a conserved arginine-patch motif in Rho protein family. BNIPL-1 has function in suppressing cell growth through binding to MIF (macrophage migration inhibitory factor) and GFER (growth factor erv1(saccharomyces cerevisiae)-like). BNIPL-2 may suppress the Cdc42GAP’s activity through ineracting with Cdc42GAP. BNIPL-2, containg a key BCH domain, which may induce the cell pseudopod growth, takes part in modulating cell migrations. Thus it suggested BNIPL-2 implicated in cell migration progresses and tumor translocation.

BNIPL Related Studies

1. Shen L, et al. (2003) The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. FEBS. 540(1-3): 86-90.
2. Qin WX, et al. (2003) BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. Biochemical and Biophysical Research Communications. 308(2): 379-85.
3. Yasuda M, et al. (1999) BNIP3 alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res. 59 (3): 533–7.