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BMPR2 Protein & Antibody

Bone Morphogenetic Protein Receptor, type II

BMPR2 Products

BMPR2 Protein, Recombinant
Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BMPR2 Human BMPR2/Fc Protein, Recombinant 10551-H03H
BMPR2 Human BMPR2 Protein, Recombinant 10551-H08H
BMPR2 Antibody
Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
BMPR2
WB, ELISA Rabbit Polyclonal Antibody 10551-RP01
Human
BMPR2
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10551-RP02
BMPR2 cDNA Clone
Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BMPR2 Human Homo sapiens BMPR2 cDNA Clone(NM_001204.6) HG10551-M

BMPR2 Alternative Names

BMPR2, BMPR-II, BMPR3, BMR2, BRK-3, FLJ41585, FLJ76945, PPH1, T-ALK [Homo sapiens]

Bmpr2, BMPR-II, BMPRII, BMP-2, 2610024H22Rik, AL117858, AW546137, BB189135 [Mus musculus]

BMPR2 Related Areas

Neuroscience>>Axon Guidance>>BMP Family>>BMPR2

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>BMPR2

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>BMPR2

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>BMPR2

BMPR2 Related Products

Protein Products
Molecule Species Description //For Detailed Info. and Price------CLICK!
BMP-2 Human BMP-2/Fc Protein, Recombinant
BMP-2 Human BMP-2 Protein, Recombinant (Activity)
BMP-5 Human BMP-5/Fc Protein, Recombinant
ALK-3/BMPR1A Human ALK-3/BMPR1A/Fc Protein, Recombinant
ALK-3/BMPR1A Human ALK-3/BMPR1A/Fc Protein, Recombinant
NBL1/DAND1 Human NBL1/DAND1/Fc Protein, Recombinant
NBL1/DAND1 Human NBL1/DAND1 Protein, Recombinant
FLRG/FSTL3 Mouse FLRG/FSTL3 Protein, Recombinant
Noggin Human Noggin/Fc Protein, Recombinant
Sclerostin/SOST Human Sclerostin/SOST Protein, Recombinant
Antibody Products
Molecule Application Description //For Detailed Info. and Price------CLICK!
Human Sclerostin/SOST WB Mouse Monoclonal Antibody
Human Sclerostin/SOST ELISA Rabbit Polyclonal Antibody
cDNA Clone Products
Molecule Species Description //For Detailed Info. and Price------CLICK!
BMP-2 Human Homo sapiens BMP-2 cDNA Clone(NM_001200.2)
BMP-3b/GDF-10 Human Homo sapiens BMP-3b/GDF-10 cDNA Clone(NM_004962.2)
BMP-3 Mouse Mus musculus BMP-3 cDNA Clone
BMP-4 Human Homo sapiens BMP-4 cDNA Clone(NM_001202.3)
BMP-5 Human Homo sapiens BMP-5 cDNA Clone(NM_021073.2)
BMP-7 Human Homo sapiens BMP-7 cDNA Clone(NM_001719.2)
GDF-2/BMP-9 Human Homo sapiens GDF-2/BMP-9 cDNA Clone(NM_016204.1)
GDF-2/BMP-9 Mouse Mus musculus GDF-2/BMP-9 cDNA Clone
ALK-3/BMPRIA Human Homo sapiens ALK-3/BMPR1A cDNA Clone(NM_004329.2)
ALK-6/BMPR1B Human Homo sapiens ALK-6/BMPR1B cDNA Clone(NM_001203.2)
BMPR2 Human Homo sapiens BMPR2 cDNA Clone(NM_001204.6)
BAMBI/NMA Human Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Cerberus 1 Human Homo sapiens Cerberus 1 cDNA Clone(NM_005454.2)
Chordin-Like 1/CHRDL1 Human Homo sapiens CHRDL1 cDNA Clone(NM_145234.2 )
CER2/DAND5 Human Homo sapiens CER2/DAND5 cDNA Clone(NM_152654.2)
NBL1/DAND1 Human Homo sapiens NBL1/DAND1 transcript variant 2 cDNA Clone(NM_005380.4)
Follistatin Human Homo sapiens Follistatin cDNA Clone(NM_013409.1)
Noggin Human Homo sapiens Noggin cDNA Clone(NM_005450.4)
Tsukushin/TSK Human Homo sapiens Tsukushin/TSK cDNA Clone(NM_015516.3)

BMPR2 Background

The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signaling leads to exaggerated TGF-beta signaling and altered cellular responses to TGF-beta. In endothelial cells, BMPR2 mutation increases the susceptibility of cells to apoptosis. BMPR2 transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. The intracellular domain of BMPR2 is both necessary and sufficient for receptor complex interaction. It had been identified that BMPR2 plays a key role in cell growth. Its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. The C-terminal tail of BMPR2 provides binding sites for a number of regulatory proteins that may initiate Smad-independent signalling. BMPR2 mutations were predicted to alter the BMP and TGF-b1/SMAD signalling pathways, resulting in proliferation rather than apoptosis of vascular cells, and greatly increase the risk of developing severe pulmonary arterial hypertension. BMPR2 gene result in familial Primary pulmonary hypertension (PPH) transmitted as an autosomal dominant trait, albeit with low penetrance. Heterozygous germline mutations of BMPR2 gene have been identified in patients with familial and sporadic PPH, indicating that BMPR2 may contribute to the maintenance of normal pulmonary vascular structure and function. Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR2 and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. BMPR2 and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH.

BMPR2 Related Studies

  1. Machado RD, et al. (2003) Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum Mol Genet. 12(24): 3277-86.
  2. Abramowicz MJ, et al. (2003) Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation. Eur Respir J. 22(3): 560-2.
  3. Hassel S, et al. (2004) Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 4(5): 1346-58.
  4. Beppu H, et al. (2005) Generation of a floxed allele of the mouse BMP type II receptor gene. Genesis. 41(3): 133-7.
  5. Morrell NW. (2006) Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling? Proc Am Thorac Soc. 3(8): 680-6.
  6. Nasim MT, et al. (2008) Stoichiometric imbalance in the receptor complex contributes to dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension. Hum Mol Genet. 217(11): 1683-94.

 

BMPR2 related areas, pathways, and other information

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