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> BMPR2 Protein & Antibody BMPR2 Protein & Antibody
Bone Morphogenetic Protein Receptor, type II
BMPR2 Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| BMPR2 | Human | BMPR2/Fc Protein, Recombinant | 10551-H03H |
| BMPR2 | Human | BMPR2 Protein, Recombinant | 10551-H08H |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human BMPR2 |
WB, ELISA | Rabbit Polyclonal Antibody | 10551-RP01 |
| Human BMPR2 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10551-RP02 |
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| BMPR2 | Human | Homo sapiens BMPR2 cDNA Clone(NM_001204.6) | HG10551-M |
BMPR2 Alternative Names
BMPR2, BMPR-II, BMPR3, BMR2, BRK-3, FLJ41585, FLJ76945, PPH1, T-ALK [Homo sapiens]
Bmpr2, BMPR-II, BMPRII, BMP-2, 2610024H22Rik, AL117858, AW546137, BB189135 [Mus musculus]
BMPR2 Related Areas
Neuroscience>>Axon Guidance>>BMP Family>>BMPR2
Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>BMPR2
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>BMPR2
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>BMPR2
BMPR2 Related Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| BMP-2 | Human | BMP-2/Fc Protein, Recombinant |
| BMP-2 | Human | BMP-2 Protein, Recombinant (Activity) |
| BMP-5 | Human | BMP-5/Fc Protein, Recombinant |
| ALK-3/BMPR1A | Human | ALK-3/BMPR1A/Fc Protein, Recombinant |
| ALK-3/BMPR1A | Human | ALK-3/BMPR1A/Fc Protein, Recombinant |
| NBL1/DAND1 | Human | NBL1/DAND1/Fc Protein, Recombinant |
| NBL1/DAND1 | Human | NBL1/DAND1 Protein, Recombinant |
| FLRG/FSTL3 | Mouse | FLRG/FSTL3 Protein, Recombinant |
| Noggin | Human | Noggin/Fc Protein, Recombinant |
| Sclerostin/SOST | Human | Sclerostin/SOST Protein, Recombinant |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! |
| Human Sclerostin/SOST | WB | Mouse Monoclonal Antibody |
| Human Sclerostin/SOST | ELISA | Rabbit Polyclonal Antibody |
BMPR2 Background
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signaling leads to exaggerated TGF-beta signaling and altered cellular responses to TGF-beta. In endothelial cells, BMPR2 mutation increases the susceptibility of cells to apoptosis. BMPR2 transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. The intracellular domain of BMPR2 is both necessary and sufficient for receptor complex interaction. It had been identified that BMPR2 plays a key role in cell growth. Its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. The C-terminal tail of BMPR2 provides binding sites for a number of regulatory proteins that may initiate Smad-independent signalling. BMPR2 mutations were predicted to alter the BMP and TGF-b1/SMAD signalling pathways, resulting in proliferation rather than apoptosis of vascular cells, and greatly increase the risk of developing severe pulmonary arterial hypertension. BMPR2 gene result in familial Primary pulmonary hypertension (PPH) transmitted as an autosomal dominant trait, albeit with low penetrance. Heterozygous germline mutations of BMPR2 gene have been identified in patients with familial and sporadic PPH, indicating that BMPR2 may contribute to the maintenance of normal pulmonary vascular structure and function. Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR2 and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. BMPR2 and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH.
BMPR2 Related Studies
- Machado RD, et al. (2003) Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum Mol Genet. 12(24): 3277-86.
- Abramowicz MJ, et al. (2003) Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation. Eur Respir J. 22(3): 560-2.
- Hassel S, et al. (2004) Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Proteomics. 4(5): 1346-58.
- Beppu H, et al. (2005) Generation of a floxed allele of the mouse BMP type II receptor gene. Genesis. 41(3): 133-7.
- Morrell NW. (2006) Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling? Proc Am Thorac Soc. 3(8): 680-6.
- Nasim MT, et al. (2008) Stoichiometric imbalance in the receptor complex contributes to dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension. Hum Mol Genet. 217(11): 1683-94.
