All BMPRIB reagents are produced in house and quality controlled, including 5 BMPRIB Antibody, 36 BMPRIB Gene, 3 BMPRIB Lysate, 3 BMPRIB Protein, 3 BMPRIB qPCR. All BMPRIB reagents are ready to use.
Recombinant BMPRIB proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-human IgG1-Fc, N-GST & His.
BMPRIBantibodies are validated with different applications, which are ELISA, WB, IHC-P.
BMPRIBcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BMPRIB of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.