BMP-5 Protein

Bone Morphogenetic Protein 5

BMP-5 Products

BMP-5 Protein, Recombinant

Molecule	Species	Description	Cat. No
BMP-5	Human	BMP-5/Fc Protein, Recombinant	10214-H01H

BMP-5 cDNA Clone

Molecule	Species	Description	Cat. No
BMP-5	Human	BMP-5 cDNA Clone / ORF Clone	HG10214-M
BMP-5	Mouse	BMP-5 cDNA Clone / ORF Clone	MG50703-M
BMP-5	Cynomolgus	BMP5 cDNA Clone / ORF Clone	MG50703-M

BMP-5 Alternative Names

BMP-5, BMP5

BMP-5 Related Areas

Neuroscience>>Axon Guidance>>BMP Family>>BMP-5

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>BMP-5

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>BMP Family>>BMP-5

BMP-5 Related Products

Protein Products

Molecule	Species	Description
BMP-2	Human	BMP-2/Fc Protein, Recombinant
BMP-2	Human	BMP-2 Protein, Recombinant BMP-2 protein (10426-HNAE) Activity: The ED50 is typically 0.5-0.9μg/ml. Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells.
ALK-3/BMPR1A	Human	ALK-3/BMPR1A/Fc Protein, Recombinant
ALK-3/BMPR1A	Mouse	ALK-3/BMPR1A/Fc Protein, Recombinant
BMPR2	Human	BMPR2/Fc Protein, Recombinant
BMPR2	Human	BMPR2 Protein, Recombinant
NBL1/DAND1	Human	NBL1/DAND1/Fc Protein, Recombinant
NBL1/DAND1	Human	NBL1/DAND1 Protein, Recombinant
FLRG/FSTL3	Mouse	FLRG/FSTL3 Protein, Recombinant
Noggin	Human	Noggin/Fc Protein, Recombinant
Sclerostin/SOST	Human	Sclerostin/SOST Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Sclerostin/SOST	WB	Mouse Monoclonal Antibody
Human Sclerostin/SOST	ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description
BMP-2	Human	Homo sapiens BMP-2 cDNA Clone(NM_001200.2)
BMP-3b/GDF-10	Human	Homo sapiens BMP-3b/GDF-10 cDNA Clone(NM_004962.2)
BMP-3	Mouse	Mus musculus BMP-3 cDNA Clone
BMP-4	Human	Homo sapiens BMP-4 cDNA Clone(NM_001202.3)
BMP-7	Human	Homo sapiens BMP-7 cDNA Clone(NM_001719.2)
GDF-2/BMP-9	Human	Homo sapiens GDF-2/BMP-9 cDNA Clone(NM_016204.1)
GDF-2/BMP-9	Mouse	Mus musculus GDF-2/BMP-9 cDNA Clone
ALK-3/BMPRIA	Human	Homo sapiens ALK-3/BMPR1A cDNA Clone(NM_004329.2)
ALK-6/BMPR1B	Human	Homo sapiens ALK-6/BMPR1B cDNA Clone(NM_001203.2)
BMPR2	Human	Homo sapiens BMPR2 cDNA Clone(NM_001204.6)
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Cerberus 1	Human	Homo sapiens Cerberus 1 cDNA Clone(NM_005454.2)
Chordin-Like 1/CHRDL1	Human	Homo sapiens CHRDL1 cDNA Clone(NM_145234.2 )
CER2/DAND5	Human	Homo sapiens CER2/DAND5 cDNA Clone(NM_152654.2)
NBL1/DAND1	Human	Homo sapiens NBL1/DAND1 transcript variant 2 cDNA Clone(NM_005380.4)
Follistatin	Human	Homo sapiens Follistatin cDNA Clone(NM_013409.1)
Noggin	Human	Homo sapiens Noggin cDNA Clone(NM_005450.4)
Tsukushin/TSK	Human	Homo sapiens Tsukushin/TSK cDNA Clone(NM_015516.3)

BMP-5 Background

Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily. In agreement with a possible role in the control of cell death, BMP-5 exhibited a regulated pattern of expression in the interdigital tissue. Transcripts of BMP-5 and BMP-5 protein were abundant within the cytoplasm of the fragmenting apoptotic interdigital cells in a way suggesting that delivery of BMPs into the tissue is potentiated during apoptosis. Gain-of-function experiments demonstrated that BMP-5 has the same effect as other interdigital BMPs inducing apoptosis in the undifferentiated mesoderm and growth in the prechondrogenic mesenchyme. BMP-5 is a member of the 60A subgroup of BMPs, other members of which have been shown to stimulate dendritic growth in central and peripheral neurons. The signaling pathway that mediates the dendrite-promoting activity of BMP-5 may involve binding to BMPR-IA and activation of Smad-1, and relative levels of BMP antagonists such as noggin and follistatin may modulate BMP-5 signaling. Since BMP-5 is expressed at relatively high levels not only in the developing but also the adult nervous system, these findings suggest the possibility that BMP-5 regulates dendritic morphology not only in the developing, but also the adult nervous system. BMP-5 may play important roles not only in myocardial differentiation, but also in the formation and maintenance of endocardial cushion tissue. Additionally, high expression level of BMP-5 has been detected in certain tumors of mesenchymal origin.

BMP-5 Related Studies

1. Yamagishi T, et al. (2001) Expression of bone morphogenetic protein-5 gene during chick heart development: possible roles in valvuloseptal endocardial cushion formation. Anat Rec. 264(4): 313-6.
2. Beck HN, et al. (2001) Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci. 2:12.
3. Zuzarte-Luís V, et al. (2004) A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol. 272(1): 39-52.