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BMP-2 Protein, Antibody, ELISA Kit, cDNA Clone

Human BMP-2  Protein

Description: Active
Expression host: Human Cells
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10426-H01H-10
10426-H01H-20
10 µg / $198
20 µg / $348
Add to Cart
Description: Active
Expression host: E. coli
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10426-HNAE-500
10426-HNAE-5
10426-HNAE-1
10426-HNAE-20
10426-HNAE-100
500 µg / $1898
5 µg / $58
1 mg / $2998
20 µg / $198
100 µg / $598
Add to Cart

Danio rerio (zebrafish) BMP-2  Protein

Description: Active
Expression host: E. coli
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63003-ZNAE-5
63003-ZNAE-100
63003-ZNAE-20
5 µg / $38
100 µg / $698
20 µg / $178
Add to Cart

BMP-2  Related Areas

BMP-2  Related Pathways

BMP-2  Related Product

BMP-2  Summary & Protein Information

BMP-2  Related Information

BMP-2  Background

Gene Summary: The BMP-2 protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. BMP-2, the encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
General information above from NCBI
Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity).
Subcellular location: Secreted.
Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Sequence similarity: Belongs to the TGF-beta family.
General information above from UniProt

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.

BMP-2  Alternative Name

BMP-2  Related Studies

  • Jiao X, et al. (2007) Heparan sulfate proteoglycans (HSPGs) modulate BMP-2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 282(2):1080-6.
  • Michon F, et al. (2008) BMP-2 and BMP-7 play antagonistic roles in feather induction. Development 135 (16):2797-805.
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