Gene Summary: The BMP-2 protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. BMP-2, the encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.General information above from NCBI
Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity).
Subcellular location: Secreted.
Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Sequence similarity: Belongs to the TGF-beta family.
General information above from UniProt