All BMF reagents are produced in house and quality controlled, including 2 BMF Antibody, 14 BMF Gene, 1 BMF Protein, 1 BMF qPCR. All BMF reagents are ready to use.
Recombinant BMF proteins are expressed by E. coli with fusion tags as N-His.
BMFantibodies are validated with different applications, which are ELISA.
BMFcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BMF of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.