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BLyS / TNFSF13B Protein (BAFF, CD257 Protein)

B-Lymphocyte Stimulator / Tumor Necrosis Factor (ligand) Superfamily, member 13B (B-cell Activating Factor, Cluster of Differentiation 257)

BLyS / TNFSF13B Products

BLyS / TNFSF13B Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BLyS/TNFSF13B Human BLyS/TNFSF13B Protein, Recombinant 10056-H01H
BLyS/TNFSF13B Human BLyS/TNFSF13B Protein, Recombinant 10056-HNCH
BLyS/TNFSF13B Human BLyS/TNFSF13B Protein, Recombinant, with Native 10056-HNAE
BLyS/TNFSF13B Cynomolgus Cynomolgus BAFF / TNFSF13B Protein 90267-C01H

  10056-H01H:  The EC50 of human TNFRSF17 is 0.07 µg/mL. Measured by its binding ability in a functional ELISA Immobilized recombinant human BAFF at 1 µg/mL (100 µl/well) can bind human TNFRSF17.

  10056-HNCH:  The ED50 for this effect is typically 0.4-2 ng/mL in the presence of goat anti-mouse IgM µ chain. Measured in a cell proliferation assay using anti­IgM stimulated mouse B cells.

BLyS / TNFSF13B Antibody

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BLyS/TNFSF13B Human BAFF / TNFSF13B Antibody 10056-MM08

BLyS / TNFSF13B Cell Lysates

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BLyS/TNFSF13B Human Human BAFF / TNFSF13B Human Cells Transfected Lysate (positive control) (denatured) 10056-H01HL
BLyS/TNFSF13B Human Human BAFF / TNFSF13B Human Cells Transfected Lysate (positive control) (denatured) 10056-HNCHL
BLyS/TNFSF13B Cynomolgus Cynomolgus BAFF / TNFSF13B Human Cells Transfected Lysate (positive control) (denatured) 90267-C01HL

BLyS / TNFSF13B cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
BLyS/TNFSF13B Human Homo sapiens BLyS/TNFSF13B cDNA Clone(NM_006573.3) HG10056-M
BLyS/TNFSF13B Mouse Mus musculus BLyS/TNFSF13B cDNA Clone MG50352-M
BLyS/TNFSF13B Mouse Mouse BAFFR/TNFRSF13C Gene cDNA Clone / ORF Clone MG50353-M
BLyS/TNFSF13B Cynomolgus Cynomolgus monkey TNFSF13B Gene cDNA Clone / ORF Clone CG90267-G

BLyS / TNFSF13B Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>BLyS/TNFSF13B/CD257

Immunology>>Cytokine & Receptor>>TNF Superfamily>>BLyS/TNFSF13B/CD257

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Co-stimulatory Molecules>>BLyS/TNFSF13B/CD257

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>BLyS/TNFSF13B/CD257

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>BLyS/TNFSF13B/CD257

BLyS / TNFSF13B Alternative Names

BLYS, TNFSF13B, BAFF, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4 [Homo sapiens]

BlyS, Tnfsf13b, BAFF, D8Ertd387e, MGC124060, MGC124061, TALL-1, TALL1, THANK, TNFSF20, zTNF4 [Mus musculus]

BLyS / TNFSF13B Background

B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS as an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.

BLyS / TNFSF13B Related Studies

  1. Nardelli B, et al. (2002) B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leuk Lymphoma. 43(7): 1367-73.
  2. Stohl W. (2006) Therapeutic targeting of B lymphocyte stimulator (BLyS) in the rheumatic diseases. Endocr Metab Immune Disord Drug Targets. 6(4): 51-8.
  3. Cancro MP, et al. (2009) The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest. 119(5): 1066-73.

 

BLyS/TNFSF13B related areas, pathways, and other information

TNF Superfamily Ligands

  • EDA-A1 / Ectodysplasin-A1*
  • TNFSF6 / CD95L / CD178*
  • TNFSF12 / TWEAK*
  • TNFSF13 / CD256*
  • TNFSF3 / TNFC / lymphotoxin beta*
  • TNFSF4*
  • TNFSF15*

TNF Receptor Superfamily

  • TNFRSF3 / CD18 / LTBR*
  • TNFRSF10C / CD263 / TRAILR3*
  • TNFRSF18*
  • TNFRSF12A / FN14 / TWEAKR*
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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