BLMH / Bleomycin Hydrolase Protein

BLMH / Bleomycin Hydrolase Products

BLMH / Bleomycin Hydrolase Protein, Recombinant

Molecule	Species	Description	Cat. No
BLMH/Bleomycin Hydrolase	Human	BLMH/Bleomycin Hydrolase Protein, Recombinant	11333-H07E
BLMH/Bleomycin Hydrolase	Mouse	BLMH/Bleomycin Hydrolase Protein, Recombinant	50668-M07E

  11333-H07E: The specific activity is > 500 pmoles / min / µg. Measured by its ability to hydrolyze Met-AMC.

  50668-M07E: The specific activity is > 500 pmoles / min / µg. Measured by its ability to hydrolyze Met-AMC.

BLMH / Bleomycin Hydrolase Antibody

Molecule	Application	Description	Cat. No
Mouse BLMH/Bleomycin Hydrolase	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50668-RP02
Human BLMH/Bleomycin Hydrolase	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11333-RP02

BLMH / Bleomycin Hydrolase cDNA Clone

Molecule	Species	Description	Cat. No
BLMH/Bleomycin Hydrolase	Human	Homo sapiens BLMH/Bleomycin Hydrolase cDNA Clone	HG11333-M
BLMH/Bleomycin Hydrolase	Mouse	Mouse BLMH/Bleomycin Hydrolase cDNA Clone / ORF Clone	MG50668-M

BLMH / Bleomycin Hydrolase Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>BLMH/Bleomycin Hydrolase

BLMH / Bleomycin Hydrolase Alternative Names

BLMH, Bleomycin Hydrolase, BH, BMH [Homo sapiens]

Blmh, Bleomycin Hydrolase, RP23-100P23.3, AI035728, Bh, Bmh, MGC36899, MGC37104, MGC39026 [Mus musculus]

BLMH / Bleomycin Hydrolase Background

The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide anticancer agent. BLMH is an essential protectant against BLM-induced death and has an important role in neonatal survival and in maintaining epidermal integrity. Sequencing revealed several putative sites phosphorylated by different types of protein kinases, but no signal sequence, transmembrane domain, N-linked glycosylation site or DNA-binding motif.

BLMH / Bleomycin Hydrolase Related Studies

1. Takeda A, et al. (1996) Cloning and Analysis of cDNA Encoding Rat Bleomycin Hydrolase, a DNA-Binding Cysteine Protease. J Biochem. 120 (2): 353-9.
2. Lefterov IM, et al. (2000) Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. The FASEB Journal. 14(12): 1837-47.
3. Brömme D, et al. (1996) Human Bleomycin Hydrolase:  Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization. Biochemistry. 35 (21): 6706–14.