BIN1 Protein

Myc box-dependent-interacting protein 1 / Bridging integrator 1

BIN1 Products

BIN1 Protein, Recombinant

Molecule	Species	Description	Cat. No
BIN1	Human	BIN1Protein, Recombinant	11361-H07E

BIN1 cDNA Clone

Molecule	Species	Description	Cat. No
BIN1	Human	Human BIN1 cDNA Clone / ORF Clone	HG11361-M

BIN1 Related Areas

Cancer>>Cell Cycle>>Cell Cycle Inhibitor>>BIN1

Signal Transduction>>Translational Regulator>>BIN1

BIN1 Alternative Names

BIN1, AMPH2, AMPHL, DKFZp547F068, MGC10367, SH3P9 [Homo sapiens]

Bin1, ALP-1, Amphl, BRAMP-2, SH3P9 [Mus musculus]

BIN1 Background

The BIN1 protein, which is encoded by the BIN1 gene, belongs to Myc-interacting protein family which is one of the nucleocytoplasmic adaptor proteins. The BIN1 protein can interact with the functionally critically Myc-box region at the N-terminal of the Myc oncoprotein, with a feature of tumor suppressor. Myc family proteins promote proliferation, growth, and apoptosis and, when deregulated, are profoundly involved in the genesis of an extraordinarily wide range of cancers. Although BIN1 is expressed in many normal cells, its levels were greatly reduced or undetectable in 14/27 carcinoma cell lines and 3/6 primary breast tumours. Deficits were functionally Although BIN1 is expressed in many normal cells, its levels were greatly reduced or undetectable in 14/27 carcinoma cell lines and 3/6 primary breast tumours. Deficits were functionally significant because ectopic expression of BIN1 inhibited the growth of tumour cells lacking endogenous message. We conclude that BIN1 is an MYC-interacting protein with features of a tumour suppressor.

BIN1 Related Studies

1. Eisenman RN. (2001) Deconstructing Myc. Genes & Dev. 15: 2023-30
2. Bouchard C, et al. (1998) Control of cell proliferation by Myc. Trends in Cell Biology. 8(5): 202-6.
3. Sakamurol D, et al. (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nature Genetics. 14: 69-77.