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BIN1  Protein, Antibody, ELISA Kit, cDNA Clone

BIN1 Related Area

BIN1 Related Pathways

    BIN1 Summary & Protein Information

    BIN1 Background

    Gene Summary: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
    General information above from NCBI
    Catalytic activity: 0
    Cofactor: 0
    Enzyme regulation: 0
    Subunit structure: Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts (SH3 domain) with HCV NS5A. {ECO:0000250, ECO:0000269|PubMed:10903846, ECO:0000269|PubMed:16530520, ECO:0000269|PubMed:9603201}.
    Domain: 0
    Subcellular location: Isoform BIN1: Nucleus.; Isoform IIA: Cytoplasm.
    Tissue specificity: Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle. {ECO:0000269|PubMed:10903846}.
    Developmental stage: 0
    Induction: 0
    Post-translational: Phosphorylated by protein kinase C. {ECO:0000250}.
    Involvement in disease: Myopathy, centronuclear, 2 (CNM2) [MIM:255200]: A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. {ECO:0000269|PubMed:17676042}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Contains 1 BAR domain. {ECO:0000255|PROSITE-ProRule:PRU00361}.; Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.
    General information above from UniProt

    BIN1 Alternative Name

    AMPH2,AMPHL,SH3P9, [homo-sapiens]
    BIN1,DKFZp547F068,MGC10367,SH3P9,AMPH2,AMPHL, [human]
    Amphl,BRAMP-2,SH3P9,ALP-1,Bin1, [mouse]
    Alp-1,Amphl,SH3P9,BRAMP-2, [mus-musculus]

    BIN1 Related Studies

  • Eisenman RN. (2001) Deconstructing Myc. Genes & Dev. 15: 2023-30
  • Bouchard C, et al. (1998) Control of cell proliferation by Myc. Trends in Cell Biology. 8(5): 202-6.
  • Sakamurol D, et al. (1996) BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nature Genetics. 14: 69-77.