BID Protein & Antibody

BH3 interacting domain death agonist

BID Products

BID Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
BID	Human	BID Protein, Recombinant	10468-HNCE
BID	Mouse	BID Protein, Recombinant, with GST Tag	50351-M20E

BID Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human BID	WB,ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10468-RP02
Human BID	WB,ELISA	BID Antibody	10468-MM02
Human BID	WB,ELISA	BID Antibody ( FITC )	10468-MM10-F

BID cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
BID	Human	Homo sapiens BID cDNA Clone	HG10468-M
BID	Mouse	Mus musculus BID cDNA Clone	MG50351-M

BID Related Areas

Cancer>>Apoptosis>>Bcl-2 Family>>BID

BID Alternative Names

BID, FP497, MGC15319, MGC42355 [Homo sapiens]

Bid, 2700049M22Rik, AI875481, AU022477 [Mus musculus]

BID Background

The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

BID Related Studies

1. Gross A. (2006) BID as a double agent in cell life and death. Cell Cycle. 5(6): 582-4.
2. Yin XM. (2007) Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene. 369: 7-19.
3. Esposti MD. (2002) The roles of Bid. Apoptosis. 7(5): 433-40.
4. Yin XM. (2000) Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res. 10(3): 161-7.
5. Yin XM. (2000) Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. J Mol Med. 78(4): 203-11.