All Beclin 1/BECN1 reagents are produced in house and quality controlled, including 1 Beclin 1/BECN1 Antibody, 23 Beclin 1/BECN1 Gene, 2 Beclin 1/BECN1 qPCR. All Beclin 1/BECN1 reagents are ready to use.
Beclin 1/BECN1 antibodies are validated with different applications, which are WB, IHC-P.
Beclin 1/BECN1 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Beclin 1/BECN1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
BECN1 (Beclin 1), a highly conserved eukaryotic protein, is a key regulator of autophagy, a cellular homeostasis pathway, and also participates in vacuolar protein sorting, endocytic trafficking, and apoptosis. BECN1 is important for embryonic development, the innate immune response, tumor suppression, and protection against neurodegenerative disorders, diabetes, and heart disease. BECN1 mediates autophagy as a core component of the class III phosphatidylinositol 3-kinase complexes.The decreased mRNA expression of the autophagy gene BECN1 may contribute to the pathogenesis and progression of HER2-enriched, basal-like, and TP53 mutant breast cancers. BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells. Despite its significant role in a number of cellular and physiological processes, the exact function of BECN1 in autophagy remains controversial.