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BDNF Protein, Antibody, ELISA Kit, cDNA Clone

BDNF Related Areas

BDNF Related Pathways

BDNF Related Product

BDNF Summary & Protein Information

BDNF Related Information

BDNF Background

Gene Summary: The protein encoded by this BDNF gene is a member of the nerve growth factor family. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this BDNF gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
General information above from NCBI
Subunit structure: Monomers and homodimers. Binds to NTRK2/TRKB.
Subcellular location: Secreted.
Tissue specificity: Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
Post-translational: The propeptide is N-glycosylated and glycosulfated.
Converted into mature BDNF by plasmin (PLG) (By similarity).
Involvement in disease: Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the NGF-beta family.
General information above from UniProt

BDNF is a member of the nerve growth factor family. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

BDNF Alternative Name

abrineurin,ANON2,BULN2,MGC34632,neurotrophin, [human]
anorexia BDNF,brain-derived neurotrophic factor,RP23-393E8.1, [mouse]

BDNF Related Studies

  • Zigova T, et al. (1998) Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 11(4):234-45.
  • Acheson A, et al. (1995) A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374(6521):450-3.
  • Bekinschtein P, et al. (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci. 105(7):2711-6.
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