BCRP / ABCG2 cDNA Clone: Expression and Clone Vector / Plasmid

BCRP / ABCG2 cDNA / Gene Overview

ABCG2 gene / cDNA is a protein-coding gene which located on 4q22.1. The ABCG2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.172 organisms have orthologs with human gene ABCG2.

BCRP / ABCG2 cDNA / Gene Function

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

BCRP / ABCG2 cDNA / Gene Sequence

LOCUS
LOCUS NM_004827 4445 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), transcript variant 1, mRNA.
ACCESSION
NM_004827
VERSION
NM_004827.2

This sequence information is just for reference only.

BCRP / ABCG2 Family & Reagents

BCRP / ABCG2 Gene family reagents (Blood group antigens)

Approved Symbol Reagent list
ABO
ART4
BSG
CD55
CD99
GYPC
XG
Approved Symbol Reagent list
ACHE
BCAM
CD44
CD59
GYPA
ICAM4
   

BCRP / ABCG2 Gene family reagents (CD molecules)

Approved Symbol Reagent list
TNFSF4
IL21R
CDH1
F11R
FASLG
CLEC10A
Clec9a
CD1D
ANPEP
TNFRSF10C
Approved Symbol Reagent list
MCAM
FCGR3B
CD177
NCR1
ICAM2
IL2RB
CD22
NRP1
MUC1
LY75

BCRP / ABCG2 cDNA / Gene Alias

  • ABCP
  • BCRP
  • CD338
  • EST157481
  • MXR

BCRP / ABCG2 cDNA / Gene Expression

Biased expression in small intestine (RPKM 33.2), duodenum (RPKM 16.6) and 12 other tissues