BCL6 Protein

BCL6 (aa 1-150) / B-cell CLL lymphoma 6 Protein

BCL6 Products

BCL6 Protein, Recombinant

Molecule	Species	Description	Cat. No
BCL6	Human	BCL6 (aa 1-150) / B-cell CLL lymphoma 6 Protein, Recombinant	12083-H30E

BCL6 cDNA Clone

Molecule	Species	Description	Cat. No
BCL6	Human	BCL6 cDNA Clone / ORF Clone	HG12083-G

BCL6 Related Areas

Cancer>>Cancer Biomarkers>> BCL6

BCL6 Alternative Names

BCL5,BCL6A,LAZ3,ZBTB27,ZNF51,B-cell lymphoma 5 protein,B-cell lymphoma 6 protein [Homo sapiens]

Bcl5, B-cell leukemia,lymphoma 5, B-cell lymphoma 6 protein homolog [Mus musculus]

BCL6 Background

The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.

BCL6 Related Studies

1. Ye BH, et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nature Genetics. 16: 161-70.
2. Seyfert VL, et al. (1996) Transcriptional repression by the proto-oncogene BCL-6. Oncogene. 12 (11) : 2331-42.
3. Chang CC, et al. (1996) BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. PNAS. 93 (14): 6947-52.