All BCL6 reagents are produced in house and quality controlled, including 2 BCL6 Antibody, 14 BCL6 Gene, 1 BCL6 Protein, 1 BCL6 qPCR. All BCL6 reagents are ready to use.
Recombinant BCL6 proteins are expressed by E. coli with fusion tags as N-Trx & His.
BCL6antibodies are validated with different applications, which are ELISA.
BCL6cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BCL6 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.