All Bim reagents are produced in house and quality controlled, including 3 Bim Antibody, 14 Bim Gene, 1 Bim Protein, 1 Bim qPCR. All Bim reagents are ready to use.
Recombinant Bim proteins are expressed by E. coli with fusion tags as N-His.
Bimantibodies are validated with different applications, which are WB, ELISA.
BimcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Bim of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymocyte-negative selection.