Bcl-XL (Protein|Antibody|cDNA Clone|ELISA Kit)

All Bcl-XL reagents are produced in house and quality controlled, including 8 Bcl-XL Antibody, 30 Bcl-XL Gene, 2 Bcl-XL IPKit, 2 Bcl-XL Protein, 2 Bcl-XL qPCR. All Bcl-XL reagents are ready to use.

Recombinant Bcl-XL proteins are expressed by E. coli with fusion tags as C-His.

Bcl-XL antibodies are validated with different applications, which are WB, ELISA, IP, FCM, IHC-P.

Bcl-XL cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Bcl-XL of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Bcl-XL Protein (2)

Species

Bcl-XL Protein, Mouse, Recombinant (aa 1-212, His Tag)

50012-M08E

Expression host: E. coli

Mouse BCL2L1/Bcl-XL Protein 11296

Bcl-XL Protein, Human, Recombinant (His Tag)

10455-H08E

Expression host: E. coli

Human BCL2L1/Bcl-XL Protein 8826
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Bcl-XL Antibody (8)

Application Clonality
Host

Anti-Bcl-XL Antibody

10455-T16

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-Bcl-XL Antibody

50012-R042

Specificity: Mouse

Application: ELISA

Clonality: MAb

Anti-Bcl-XL Antibody

50012-RP01

Specificity: Mouse

Application: ELISA

Clonality: PAb

Anti-Bcl-XL Antibody

50012-RP02

Specificity: Mouse

Application: ELISA,IHC-P

Clonality: PAb

Mouse BCL2L1/Bcl-XL Immunohistochemistry(IHC) 3379

Anti-Bcl-XL Antibody

10455-R016

Specificity: Human

Application: WB,ELISA,IP

Clonality: MAb

Human BCL2L1/Bcl-XL Immunoprecipitation(IP) 6164

Anti-Bcl-XL Antibody

10455-MM07

Specificity: Human

Application: ELISA,FCM

Clonality: MAb

Human BCL2L1/Bcl-XL Flow Cytometry (FC) 4912

Anti-Bcl-XL Antibody

101579-T32

Specificity: Human

Application: WB

Clonality: PAb

Human BCL2L1/Bcl-XL Western blot (WB) 6910

Anti-Bcl-XL Antibody

50012-R036

Specificity: Mouse

Application: WB,IP

Clonality: MAb

Mouse BCL2L1/Bcl-XL Immunoprecipitation(IP) 6211
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Bcl-XL cDNA Clone (30)

Mouse
Human

Bcl-XL qPCR Primer (2)

Bcl-XL IP Kit (2)

B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1) , belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apoptosis independent of additional signals. The crystal and solution structures of a Bcl-2 family member, Bcl-xL is like this: The structures consist of two central, primarily hydrophobic α-helices, which are surrounded by amphipathic helices. A 6-residue loop connecting helices αl and α2 was found to be flexible and non-essential for anti-apoptotic activity. Bcl-xL is chareacterized as important factors in autophagy, inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition, Beclin 1, Bcl-2 and Bcl-xL can cooperate with Atg5 or Ca2+ to regulate both autophagy and apoptosis. Bcl-xL is also implicated in anoxia induced cell death. The pathway is initiated by the loss of function of the prosurvival Bcl-2 family members Mcl-1 and Bcl-2 / Bcl-XL, resulting in Bax- or Bak-dependent release of cytochrome c and subsequent caspase-9-dependent cell death. Thus, Bcl-xL, the well-characterized apoptosis guards, appears to be important in cell death.
Protein
Antibody
Gene
qPCR
IPKit
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