All Bcl-2 reagents are produced in house and quality controlled, including 12 Bcl-2 Antibody, 1 Bcl-2 ELISA, 30 Bcl-2 Gene, 2 Bcl-2 IPKit, 1 Bcl-2 Protein, 1 Bcl-2 qPCR. All Bcl-2 reagents are ready to use.
Recombinant Bcl-2 proteins are expressed by E. coli with fusion tags as C-His.
Bcl-2antibodies are validated with different applications, which are FCM, WB, IP, ELISA, IHC-P, ELISA(Cap), ELISA(Det).
Bcl-2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Bcl-2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Bcl-2ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes. It is expressed in a variety of tissues. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.