BCHE / Butyrylcholinesterase Protein & Antibody

BCHE / Butyrylcholinesterase Products

BCHE / Butyrylcholinesterase Protein, Recombinant

Molecule	Species	Description	Cat. No
BCHE/Butyrylcholinesterase	Human	BCHE/Butyrylcholinesterase Protein, Recombinant	12010-H08H
BCHE/Butyrylcholinesterase	Mouse	BCHE/Butyrylcholinesterase Protein, Recombinant	50418-M08H

  12010-H08H:  The specific activity is > 50,000 pmoles/min/μg.Measured by its ability to cleave Butyrylthiocholine.

  50418-M08H:  The specific activity is > 300 nmol/min/µg. Measured by its ability to cleave Butyrylthiocholine.

BCHE / Butyrylcholinesterase Antibody

Molecule	Application	Description	Cat. No
Mouse BCHE/Butyrylcholinesterase	WB, ELISA	BCHE/Butyrylcholinesterase Antibody, Rabbit PAb	50418-RP01
Mouse BCHE/Butyrylcholinesterase	WB, ELISA	BCHE/Butyrylcholinesterase Antibody, Rabbit PAb (Antigen Affinity Purified)	50418-RP02

BCHE / Butyrylcholinesterase cDNA Clone

Molecule	Species	Description	Cat. No
BCHE/Butyrylcholinesterase	Human	Homo sapiens BCHE/Butyrylcholinesterase cDNA Clone	HG12010-G
BCHE/Butyrylcholinesterase	Mouse	Mus musculus BCHE/Butyrylcholinesterase cDNA Clone	MG50418-M

BCHE / Butyrylcholinesterase Related Areas

Enzyme>>Lipid Metabolism Enzymes>>BCHE/Butyrylcholinesteras

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>BCHE/Butyrylcholinesteras

BCHE / Butyrylcholinesterase Alternative Names

BCHE, Butyrylcholinesterase, CHE1, E1, acylcholine acylhydrolase, butyrylcholine esterase, choline esterase II, cholinesterase, cholinesterase 1, pseudocholinesterase [Homo sapiens]

Bche, Butyrylcholinesterase, C730038G20Rik, MGC107651, acylcholine acylhydrolase, butyrylcholine esterase, choline esterase II, cholinesterase, pseudocholinesterase [Mus musculus]

BCHE / Butyrylcholinesterase Background

Butyrylcholinesterase (BCHE), also known as cholinesterase or BuChE, is an enzyme defined as "pseudo" or "non-neuronal" cholinesterase. Butyrylcholinesterase (BCHE) is widely distributed in the nervous system as well as blood plasma. It is constitutively similar to the neuronal acetylcholinesterase, and is a non-specific cholinesterase which hydrolyses many different choline esters. Butyrylcholinesterase (BCHE) is a glycoprotein of 4 identical subunits, that were arranged as a dimer of dimers with each dimer composed of two identical subunits joined by interchain disulfide bonds. Butyrylcholinesterase (BCHE) behaves principally similar to the true enzyme and thus can play a similar role in nerve conduction, although it participates probably only in relatively slow conductive processes and could be involved in other nervous system functions and in neurodegenerative diseases. It can hydrolyze toxic esters such as cocaine or scavenge organophosphorus pesticides and nerve agents. Purified human serum cholinesterase combines in its active surface an anionic and an esteratic site, similar to true cholinesterase. It has been demonstrated that butyrylcholinesterase (BCHE) may have a greater role in cholinergic transmission than previously surmised, making BChE inhibition an important therapeutic goal in Alzheimer's disease.

BCHE / Butyrylcholinesterase Related Studies

1. Lockridge O. (1988) Structure of human serum cholinesterase. Bio Essays. 9(4):125–8.
2. Mesulam M, et al. (2002) Widely Spread Butyrylcholinesterase Can Hydrolyze Acetylcholine in the Normal and Alzheimer Brain. Neurobiology of Disease. 9(1): 88-93.
3. Nicolet Y, et al. (2003) Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products. The Journal of Biological Chemistry. 278: 41141-7.