All BCA-1 reagents are produced in house and quality controlled, including 3 BCA-1 Antibody, 48 BCA-1 Gene, 3 BCA-1 Protein, 2 BCA-1 qPCR. All BCA-1 reagents are ready to use.
Recombinant BCA-1 proteins are expressed by E. coli with fusion tags as N-His, Native.
BCA-1antibodies are validated with different applications, which are ELISA.
BCA-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BCA-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).